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BACKGROUND
The hydrolysis of adenine nucleotide linked to the membrane of the platelets is changed in acute myocardial infarction (AMI) probably due to a greater arterial blockage and cell damage in patients with ST elevation (STEMI) than in those without ST segment elevation (NSTEM).
METHODS
This
Obzidan was demonstrated to increase the total adenine nucleotide pool content in all zones of the hearts of male rabbits with experimental myocardial infarction. The total adenine nucleotide pool in the remote from affected zone site of the left ventricle kept exceeding the values of control ones
Recent studies have shown that vagal activation may have an important therapeutic implication for myocardial infarction (MI), but effective strategies remain unexplored. Here, we investigate whether adenine sulfate can preserve cardiac function and the cholinergic system against MI. Rats were
Recent studies have shown that vagal activation may have an important therapeutic implication for myocardial infarction (MI), but effective strategies remain unexplored. Here, we investigate whether adenine sulfate can preserve cardiac function and the cholinergic system against MI. Rats were
Preconditioning is known to decelerate degradation of the tissue adenine nucleotides during ischemia and to delay ischemic myocardial necrosis. However, it is not known whether these two phenomena are related. To obtain an insight into this question, the present study examined whether adenosine and
Turnover of heart polynucleotides, adenine nucleotides and adenosine was studied in dynamics of dog experimental myocardial infarction. In the areas of necrosis an inhibition of RNAase and DNAase was observed and later on - an activation of these enzymes with simultaneous increase in content of RNA
Samples of myocardium from four areas of ischemic and infarcted canine ventricle were examined over a 20-day period for content of the three adenine nucleotides as well as inosine, hypoxanthine, adenosine, and inosine monophosphate. The adenosine triphosphate (ATP) content of central and peripheral
The "adenosine" and "non-adenosine" mechanisms of adenine nucleotide (ATP, ADP, AMP KP) metabolism were studied in 58 patients with myocardial infarction. Predominant activation of the "adenosine" mechanism of metabolism was revealed in patients with acute myocardial infarction with a marked pain
OBJECTIVE
Acute hyperglycemia is independently associated with larger myocardial infarct size in both diabetic and nondiabetic patients. We hypothesized that the oxidative stress imposed by acute hyperglycemia contributes to the exacerbation of infarct size during reperfusion.
METHODS
C57BL/6 mice
Experiments on rabbits with experimental myocardial infarction were made to determine the content of adenyl nucleotides and Ca2+-dependent ATPase activity of myosin outside the zone of necrosis. It was found that on the 5th day the animals injected with 40 mg/kg riboxine intravenously on a daily
The development of myocardial infarction was shown to be accompanied by a rise in blood cAMP, cGMP and AMP levels, cyclic nucleotides peaking within the first hours of the disease. The increase in plasma cAMP, associated with developing heart failure, was more persistent. The administration of GIP
A close relationship between the ADN pool and one of the routes of free radical generation mediated by the xanthine oxidase system has been revealed during studies of changes in adenyl nucleotide metabolism in 140 patients with acute myocardial infarction. The metabolic disorders and changes in the
OBJECTIVE
To investigate the rate of ATP, ADP and AMP hydrolysis on the surface of platelets from acute myocardial infarction (AMI) patients.
METHODS
Twenty-five patients diagnosed with AMI, through clinical criteria, electrocardiographic changes and increase of cardiac biomarkers, as well as 25