adenosine triphosphate/atrophy

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Defective mitochondrial adenosine triphosphate production in skeletal muscle from patients with dominant optic atrophy due to OPA1 mutations.

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OBJECTIVE To assess whether impaired energy metabolism in skeletal muscle is a hallmark feature of patients with dominant optic atrophy due to several different mutations in the OPA1 gene. METHODS We used phosphorus 31 magnetic resonance spectroscopy to assess calf muscle oxidative metabolism in

Long-term fasting of donors deteriorates mitochondrial adenosine triphosphate synthesis in liver grafts during cold preservation.

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White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis.

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In patients with multiple sclerosis (MS), a diffuse axonal degeneration occurring throughout the white matter of the central nervous system causes progressive neurologic disability. The underlying mechanism is unclear. This review describes a number of pathways by which dysfunctional astrocytes in

Deficit of in vivo mitochondrial ATP production in OPA1-related dominant optic atrophy.

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Dominant optic atrophy has been associated with mutations in the OPA1 gene, which encodes for a dynamin-related GTPase, a mitochondrial protein implicated in the formation and maintenance of mitochondrial network and morphology. We used phosphorus magnetic resonance spectroscopy to assess calf

Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

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Chronic attenuation of hyperinsulinemia by diazoxide (DZ), a K-adenosine triphosphate (ATP) channel opener and an inhibitor of glucose-mediated insulin secretion, improved glucose tolerance and lipid profile and decreased the rate of weight gain in obese Zucker rats. To determine whether suppression

Protective influence of rosiglitazone against time-dependent deterioration of boar spermatozoa preserved at 17°C.

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Spermatozoa are highly specialized cells, and energy metabolism plays an important role in modulating sperm viability and function. Rosiglitazone is an antidiabetic drug in the thiazolidinedione class that regulates metabolic flexibility and glucose uptake in various cell types, but its effects on

Effect of prostacyclin and adenosine triphosphate on vasospasm of canine basilar artery.

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Cerebral vasospasm is one of the most important factors influencing morbidity and mortality of intracranial operations or diseases. Platelet aggregation and adhesion is increased in spastic vessels. Degradation of platelets liberates mediators, which in turn increase vasospasm, thus creating a

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

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Using a mouse model of burn trauma, we tested the hypothesis that severe burn trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to

Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart.

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Severe myocardial ischemia in dogs (perfusion 10% of normal) caused progressive deterioration in adenosine triphosphate (ATP) metabolism. Between 1/2 hour and 5 hours, myocardial ATP content fell from 55 to 6% of normal, and the sum of adenine nucleotides fell from 66 to 14% of normal. Moderate

Isolated cerebellar variant of adrenoleukodystrophy with a de novo adenosine triphosphate-binding cassette D1 (ABCD1) gene mutation.

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X-linked adrenoleukodystrophy (X-ALD) shows a wide range of phenotypic expression, but clinical presentation as an isolated lesion of the cerebellar white matter and dentate nuclei has not been reported. We report an unusual presentation of X-ALD only with an isolated lesion of the cerebellar white

Usefulness of immune monitoring in lung transplantation using adenosine triphosphate production in activated lymphocytes.

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BACKGROUND The ImmuKnow (Cylex Inc, Columbia, MD) assay measures the amount of adenosine triphosphate (ATP) produced by helper CD4(+) cells after stimulation with a T-cell mitogen. We hypothesized that this assay can be used to assess the immune function of lung transplant recipients and identify

Adenosine tri-phosphate (ATP)-based cleaning monitoring in health care: how rapidly does environmental ATP deteriorate?

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BACKGROUND Ensuring cleaning compliance of housekeeping staff is critical to ensure adequate application of surface disinfectants. Adenosine triphosphate (ATP) testing has been recommended as a way to monitor cleaning compliance; however, little is known about the stability of ATP on environmental

Alteration of glucose consumption and adenosine triphosphate content in bone tissue of rats with different ages: the stimulatory effect of zinc.

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The alteration in bone metabolism at different ages was investigated by estimating glucose consumption and adenosine triphosphate (ATP) content in a culture system of bone tissue from 3- and 30-week-old rats. The femoral-diaphyseal tissue was removed and cultured for periods up to 48 h in Dulbecco's

The association between early neurological deterioration and whole blood purine concentration during acute stroke.

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Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxia, may reflect the subclinical presence of

Antihyperlipidemic activity of adenosine triphosphate in rabbits fed a high-fat diet and hyperlipidemic patients.

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Context Recently, adenosine triphosphate (ATP) was occasionally found to decrease the triglyceride (TG) levels in several hyperlipidemic patients in our clinical practice. Objective The study investigates the anti-hyperlipidemic effects of ATP in a high-fat fed rabbit model and hyperlipidemic

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