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[Effects of baicalin on contents of PGE2 and cAMP in hypothalamus of fever rats].
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OBJECTIVE
Both PGE2 and cAMP are important neural mediator of fever. In order to discuss if PGE2 and cAMP are involved in the antipyretic mechanism of baicalin, fever models of rats were made by i.v. injection of endotoxin (ET). The antipyretic action and effects of baicalin on contents of PGE2 and
The effects of baicalin on the TLR2/4 signaling pathway in the peripheral blood mononuclear cells of a lipopolysaccharide-induced rat fever model.
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Baicalin, which is a flavonoid compound isolated from Scutellariae radix, has significant antipyretic effects. The aim of the present study was to evaluate the effects of baicalin on the Toll-like receptor 2/4 (TLR2/4) signaling pathway in the peripheral blood mononuclear cells (PBMCs) of a rat
The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits.
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Evidence has accumulated to indicate that systemic administration of lipopolysaccharide (LPS), in addition to elevating tumor necrosis factor-alpha (TNF-alpha) as well as fever, induces overproduction of both glutamate and hydroxyl radicals in the rabbit's hypothalamus. Current investigation was
Baicalin Augments Hyperthermia-Induced Apoptosis in U937 Cells and Modulates the MAPK Pathway via ROS Generation.
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OBJECTIVE
Hyperthermia is a widely used therapeutic tool for cancer therapy and a well-known inducer of apoptosis. Although the flavonoid compound baicalin (BCN) is a potent anticancer agent for several human carcinomas, it is less potent in the human U937 myelomonocytic leukemia cell line. To
[Separation and determination of baicalin in prescriptions containing Scutellaria baicalensis Georgi by HPCE].
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Qingkailing Oral Tonic and Shuanghuanglian Oral Tonic are two kinds of complex formlae of Chinese traditional patent medicine, and both contain Scutellaria baicalensis Georgi. Baicalin is referred to the main active component with functions of dispelling wind-heat to reduce fever and detoxicating,
[Efffect of baicalin on antipyresis and influence on cytokine].
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OBJECTIVE
To study the antipyretic effect of baicalin in inhibiting yeast-induced fever in rats and the influence on inflammatory cytokine, then explore the possible mechanism of baicalin in inhibiting yeast-induced fever in rats.
METHODS
Rat modles of pyrexia were established by subcutaneous
[Determination of baicalin and chlorogenic acid in yinhuang granule by capillary electrophoresis].
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Yinhuang Granule is a kind of complex formulae made up of extract of Flos lonicerae and that of Radix scutellariae, of the fuctions of dispelling wind-heat to reduce fever, detoxicating, relieving inflammation, promoting urination and tranquilizimg the mind and can be applied to upper respiratory
Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation.
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Baicalin is one of the main bioactive flavone glucuronides derived as a medicinal herb from the dried roots of Scutellaria baicalensis Georgi, and it is widely used for the treatment of fever, inflammation, and other conditions. Due to baicalin's poor solubility in water, its absolute
Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats.
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Qingkailing injection (QKLI) is a modern Chinese medicine preparation derived from a well-known classical formulation, An-Gong-Niu-Huang Wan. Although the clinical efficacy of QKLI has been well defined, its severe adverse drug reactions (ADRs) were extensively increased. Through thorough attempts
Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.
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Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was
Protective effects of baicalin on rabbit articular chondrocytes in vitro.
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Drug therapy is one of the typical treatments for post-injury inflammation of cartilage. Traditional Chinese herbs have potential as treatments, as their long history of clinical application has demonstrated they are effective and induce minimal side effects. Baicalin is a traditional Chinese
Anti-nociceptive mechanism of baicalin involved in intervention of TRPV1 in DRG neurons in vitro.
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BACKGROUND
Scutellaria baicalensis Georgi (Lamiaceae) is often included as an ingredient in traditional Chinese compound prescriptions for the treatment of fever-related or inflammatory conditions.
OBJECTIVE
The present work was to further uncover the analgesic mechanisms of baicalin (a known
The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke.
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The present study was performed to assess the prophylactic effect of baicalin, a flavonoid compound, in an animal model of heatstroke. Anesthetized rats, immediately before the start of heat stress, were divided into two major groups and given the following: vehicle solution (1mL per kg body weight)
Simultaneous determinations of four major bioactive components in Acacia catechu (L.f.) Willd and Scutellaria baicalensis Georgi extracts by LC-MS/MS: Application to its herb-herb interactions based on pharmacokinetic, tissue distribution and excretion studies in rats.
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Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
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Sosihotang (SO) is an herbal medication, which has been widely used to treat fever, chill and vomiting due to common cold in east-Asian countries. In this study, to provide insight into the effects of SO on inflammation, we investigated its effect on pro-inflammatory mediator production in RAW 264.7
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