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Страница 1 од 19 резултати
Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia.
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Inflammatory responses are key contributors to cancer cachexia and foster a complex cascade of biological outcomes. Baicalin is a natural compound derived from Scutellaria baicalensis that possesses anti-inflammatory properties in many diseases; therefore, the aim of this study was to verify whether
Baicalin Alleviates Age-Related Macular Degeneration via miR-223/NLRP3-Regulated Pyroptosis.
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Mechanical and baicalin delivery properties of adhesive matrices for iontophoretic flexible electrodes.
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The aim of this work was to evaluate the feasibility and efficacy of flexible adhesive electrodes (FAEs) prepared with adhesive matrices for iontophoretic delivery of baicalin, a drug used for the treatment of atopic dermatitis, viral hepatitis and HIV. Single-layer adhesive matrices (SLAMs) and
Baicalin attenuates laser-induced choroidal neovascularization.
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OBJECTIVE
To determine whether intravitreally-injected baicalin inhibits the growth of choroidal neovascularization (CNV) experimentally induced via laser photocoagulation through analysis of angiogenic factors.
METHODS
Six CNVs were induced in the left eyes of 8-week-old male Brown Norway rats.
Baicalin supplementation reduces serum biomarkers of skeletal muscle wasting and may protect against lean body mass reduction in cancer patients: Results from a pilot open-label study.
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OBJECTIVE
Muscle wasting in patients with cancer has been linked to an increased activity of nuclear factor κB (NF-κB) and higher circulating levels of activin-A (ActA), a negative growth factor for muscle mass. Baicalin is a natural flavonoid that can reduce skeletal muscle atrophy in animal models
[Protective effects of baicalin pretreatment on hypoxic-ischemic brain damage in neonatal rats].
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OBJECTIVE
Previous research suggests that dexamethasone (Dex) pretreatment protects neonatal rats against hypoxic-ischemic brain damage (HIBD). Some of the pharmacological effects of baicalin (a traditional Chinese medicine extracted from Scutellaria baicalensis Georgi) are similar to Dex. This
[Protective effects of baicalin, mannitol and dexamethasone on infective brain edema in rats].
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OBJECTIVE
To compare the therapeutic effects of baicalin, mannitol and dexamethasone on infective brain edema(IBE) in rats.
METHODS
Forty normal Sprague-Dawley(SD) rats (200 +/- 30) g by weight were divided into 5 groups randomly: (1) normal saline control group(NS, n = 8); (2) infective brain edema
[Baicalin suppresses beta-amyloid protein induced hippocampal cyclooxygenase-2 expression].
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OBJECTIVE
To study the brain protection of baicalin on rats with Alzheimer's disease (AD) and its probable mechanism of action.
METHODS
Thirty-six male healthy Wistar rats were randomly divided into the sham-operative group, the AD group, and the baicalin group, twelve in each. beta-amyloid protein
The immunoprotective activity of baicalin in mouse model of cecal ligation and puncture-induced sepsis.
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The purpose of the study was to probe the therapeutic effect of baicalin on immunosuppression in the mouse model of cecal ligation and puncture (CLP)-induced sepsis. Mouse model was established by employing the procedure of CLP. The proliferation of T lymphocytes was measured using CFDA-SE staining
[Therapeutic effect of baicalin in treatment of renal interstitial fibrosis in rats with unliateral ureteral obstruction and related mechanisms].
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OBJECTIVE
To investigate the therapeutic effect of baicalin at different doses administered for different periods of time in the treatment of renal interstitial fibrosis in rats with unliateral ureteral obstruction (UUO) and related mechanisms.
METHODS
Sixty-four Sprague-Dawley rats were randomly
[An experimental research on differentiation of mesenchymal stem cells derived from children with spinal muscular atrophy into neuron-like cells].
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OBJECTIVE
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease. It is characterized by selective loss of spinal cord motor neurons leading to muscle atrophy and is the result of mutation or deletion of the survival motor neuron (SMN) gene. Currently, there are no
Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders.
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Ocular diseases such as cataract, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are the leading causes of blindness. The elderly population is at particular risk of developing one or more of these age-related ocular diseases. By virtue of multiple bioactivities, effort
Baicalin Attenuates Mycoplasma gallisepticum-Induced Inflammation via Inhibition of the TLR2-NF-κB Pathway in Chicken and DF-1 Cells.
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Background
Previous reports demonstrated that baicalin possesses potential anti-inflammatory properties. The present study was conducted to determine the effects of baicalin against inflammatory responses in chicken and DF-1 cells infected with Mycoplasma gallisepticumProtective effects of baicalin on rabbit articular chondrocytes in vitro.
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Drug therapy is one of the typical treatments for post-injury inflammation of cartilage. Traditional Chinese herbs have potential as treatments, as their long history of clinical application has demonstrated they are effective and induce minimal side effects. Baicalin is a traditional Chinese
The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats.
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Baicalin, a flavonoid compound purified from plant Scutellaria baicalensis Georgi, has been reported to possess a wide variety of pharmacological properties including anti-oxidative, anti-apoptotic and neuroprotective properties. Oxidative stress can dramatically alter neuronal function and has been
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