Intravenous infusion of 0.125M L-glutamic acid solution at a rate of 1.65 ml/kg BW and hour commencing at or up to 20 minutes before the release of aortic cross-clamp. The infusion is continued for two hours after declamping the aorta after which an additional 50 ml is given at a halved infusion rate.

Intravenous infusion of saline at a rate of 1.65 ml/kg BW and hour commencing at or up to 20 minutes before the release of aortic cross-clamp. The infusion is continued for two hours after declamping the aorta after which an additional 50 ml is given at a halved infusion rate.

Coronary Artery Bypass Surgery

Postoperative Complications

Heart Failure

glutamate infusion

saline infusion

Uppsala University Hospital

Sahlgrenska University Hospital

Blekinge County Council Hospital

University Hospital Linköping

University Hospital Umeå

University Hospital Örebro

Glutamate for Metabolic Intervention in Coronary Surgery II

Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II

suspected unexpected serious adverse reaction

Exploratory assessment of plasma-Copeptin related to NT-proBNP

Rolf Svedjeholm

Professor, MD

University Hospital, Linkoeping

Region Örebro County

University Hospital, Umeå

Sahlgrenska University Hospital, Sweden

Intravenous infusion of 0.125 M glutamic acid solution at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

Intravenous infusion of saline at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

Intravenous infusion of 0.125 M glutamic acid solution at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.
Intravenous glutamate infusion: Intravenous infusion of 0.125 M glutamic acid solution at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

Intravenous Glutamate

Intravenous infusion of saline at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.
Intravenous infusion of saline: Intravenous infusion of isotonic saline at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

Saline Infusion

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Region of Enrollment

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

p-CK-MB postoperative day 1, p-troponin-T postoperative day 3

Degree of Perioperative Myocardial Injury

Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU

Postoperative Hemodynamic State

Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40)

Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)

maximum p-creatinine value recorded postoperatively < 30 days

Postoperative Renal Function

Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan

Number of Participants With Postoperative Stroke < 24 Hours

ICU Stay

Number of patients with atrial fibrillation recorded postoperatively

Atrial Fibrillation

Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients

Severe Circulatory Failure in CCS Class IV Patients

Late mortality - related to biochemical markers (troponin-T, mixed venous oxygen saturation, NT-proBNP) and intervention

Long-term Survival

Overall Study

Coronary Artery Bypass

Myocardial Ischemia

Myocardial Infarction

Coronary Artery Disease

Intravenous infusion of isotonic saline at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

glutamic acid/infarction

Glutamate for Metabolic Intervention in Coronary Surgery II

Glutamate for Metabolic Intervention in Coronary Surgery

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