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Pupillary capture of implantable collamer lens after oral antidepressants.

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We report the case of a 26-year-old man under treatment with the antidepressant drugs olanzapine and buspirone, which are associated with anticholinergic effects, in whom an implantable collamer lens (ICL) became spontaneously dislocated. ICL dislocation and pupil capture occurred 10 months

Phototoxicity in human lens epithelial cells promoted by St. John's Wort.

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St. John's Wort (SJW), an over-the-counter antidepressant, contains hypericin, which absorbs light in the UV and visible ranges and is phototoxic to skin. To determine if it also could be phototoxic to the eye, we exposed human lens epithelial cells to 0.1-10 microM hypericin and irradiated them

Spectroscopic study of visible-light effects on hypericin-lens proteins systems.

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Molecular interactions between hypericin and alpha-, beta- and gamma-crystallin proteins have been studied by means of absorption and steady-state fluorescence spectroscopy, aiming to clarify if and how the pigment binds to the proteins and to investigate the effects of visible-light irradiation on

A closer lens: Cancer survivors' supportive intervention preferences and interventions received.

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OBJECTIVE Cancer survivor preferences for formal interventions designed to provide psychological support remain relatively unknown. To address this gap, we evaluated cancer survivors' preferences for psychological intervention, whom they preferred to recommend such intervention, and how their

Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort).

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Hypericin is the active ingredient in the over the counter antidepressant medication St. John's Wort. Hypericin produces singlet oxygen and other excited state intermediates that indicate it should be a very efficient phototoxic agent in the eye. Furthermore it absorbs in the UV and visible range,

GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens.

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Regulated GluA2 AMPA receptor subunit expression, RNA editing, and membrane localization are fundamental determinants of neuronal Ca(2+) influx, and underlie basic functions such as memory and the primary brain disorder epilepsy. Consistent with this, AMPARs, and specifically GluA2, are targets of

Focal length variability and protein leakage as tools for measuring photooxidative damage to the lens.

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Hypericin is the ingredient used to standardize the popular over-the-counter antidepressant medication St. John's Wort. Because hypericin readily produces singlet oxygen and other excited state intermediates, it is a very efficient phototoxic agent in the eye that can potentially induce the

Drug-induced lenticular opacity and accumulation of cholesterol-related substances in the lens cortex of dogs.

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TP0446131, developed as an antidepressant agent, was found to cause lenticular opacity in a 13-week repeated-dose study in dogs. Histopathologically, the lenticular opacity was observed as a degeneration of the lens fibers, characterized by irregularity in the ordered arrangement of the fibers which

[Persistence of bilateral pigmentary deposits in stromal cornea in a woman after a brief treatment with antidepressants].

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BACKGROUND Neuropsychiatric agents may affect the eye in various ways. Phenothiazine commonly used in the treatment of depressive psychosis and schizophrenia may induce pigmentary deposits in the eyelids, conjunctiva, cornea, lens and retina. METHODS We report on a case of a 60-year-old female

The potential ocular phototoxicity of antidepressant drugs.

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Light Therapy is a new treatment for patients with Seasonal Affective Disorder (SAD), a depressive state occurring during the winter as a result of decreased sunlight. The treatment involves placing the patient in front of a light box (2-10,000 lux) for approximately 30 min to 1 hour per day during

Drivers of and Solutions for the Overuse of Antidepressant Medication in Pediatric Populations.

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Children in the United States and internationally are increasingly being diagnosed with depression and related psychiatric conditions and a recent study found that antidepressant (ADM) use in children and adolescents rose substantially in youth cohorts in five Western countries from 2005 to 2012.

Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.

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St. John's wort (SJW), an over-the-counter antidepressant, contains hypericin, which absorbs light in the UV and visible ranges. In vivo studies have determined that hypericin is phototoxic to skin and our previous in vitro studies with lens tissues have determined that it is potentially phototoxic

[Research relating the use of systematic drug and cataracts].

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Cataract is the leading cause of blindness in the world. The use of certain drugs is one of the risk factors for lens opacities, such as glucocorticoids and chlorpromazine. We reviewed new studies regarding the relationship between cataract formation and drugs that have become more widely used in

Ocular adverse effects of neuropsychiatric agents. Incidence and management.

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Neuropsychiatric agents may adversely affect the eye in various ways. The more frequently encountered effects include corneal oedema and pigmentary changes in the lens and cornea which are induced by phenothiazine derivatives; thioridazine-induced retinopathy; tricyclic antidepressant-induced

[Randomly sampling survey of dry eye awareness in general eye clinic].

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OBJECTIVE To determine the dry eye awareness in the populations visiting general eye clinic. METHODS This was a cross-sectional study. A questionnaire about dry eye was designed and administrated to Peking University Third Hospital General Eye Clinic patients (n = 804) from June 2010 to June 2011.

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