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lipoxygenase/inflammation
Врската е зачувана во таблата со исечоци
Страница 1 од 232 резултати
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
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FIELD OF THE INVENTION
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to co-administration of an inhibitor of cyclooxygenase-2 and a 5-lipoxygenase inhibitor for treating inflammation and inflammation-related disorders, such as arthritis.
BACKGROUND
Use of mizolastine for treating inflammatory diseases associated with 5-lipoxygenase
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This application is a 371 of PCT/FR98/00765, filed Apr. 16, 1998.
The present invention relates to the use of mizolastine, 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidyl]methyl amino]-4-pyrimidinol or 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidyl]methyl
Benzimidazole compounds useful for the treatment of inflammatory disease, atherosclerosis, restenosis or inhibiting lipoxygenase
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FIELD OF THE INVENTION
The present invention relates to novel compounds and medical methods of treatment of inflammation, atherosclerosis and restenosis. More particularly, the present invention concerns the use of novel benzimidazole derivatives.
BACKGROUND OF THE INVENTION
Lipoxygenases are
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
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BACKGROUND OF THE INVENTION
The present invention is directed to the provision of compounds having potent anti-inflammatory and anti-oxidant activity. The invention is further directed to compositions containing the compounds of the present invention for use in pharmaceutical applications. The
Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA.sub.2 and lipoxygenase
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This invention relates to novel substituted indene-, indole-, pyrano-indole- and tetrahydrocarbazole alkanoic acid derivatives possessing lipoxygenase inhibitory, phospholipase A.sub.2 inhibitory and leukotriene antagonist activity, which are useful as anti-inflammatory, antiallergic and
Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers, sulfoxides, and disulfides and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy
Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioalkylamides and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioalkylamides and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
Phenolic thioethers as inhbitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioether derivatives and more particularly relate to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
Phenolic thioethers as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioether derivatives and more particularly relates to the novel compounds of Formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well
Phenolic thioethers as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well recognized
Novel phenolic thioethers as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy agents.
It is well recognized
5-lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to compounds and pharmaceutical compositions which inhibit lipoxygenase and are useful as anti-inflammatory and anti-allergy agents.
It is well recognized that arachidonic acid, an essential unsaturated fatty acid,
5-lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The present invention relates to compounds and pharmaceutical compositions which inhibit lipoxygenase and are useful as anti-inflammatory and anti-allergy agents.
It is well recognized that arachidonic acid, an essential unsaturated fatty acid,
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