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Страница 1 од 69 резултати
Tumor necrosis alpha-blocking agent (etanercept): a triple blind randomized controlled trial of its use in treatment of sciatica.
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METHODS
Triple blind randomized controlled study.
OBJECTIVE
To establish the treatment effect of etanercept in acute sciatica secondary to lumbar disc herniation.
BACKGROUND
Etanercept is a selective competitor of tumor necrosis factor-alpha which is a proinflammatory cytokine. It is currently used
Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study.
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BACKGROUND
The aim of this study was to assess the efficacy and safety of tumor necrosis factor (TNF)-α inhibition with infliximab (IFX) in treating recurrent and disabling chronic sciatica pain associated with post-operative peridural lumbar fibrosis.
METHODS
A double-blind, placebo-controlled
Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica.
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METHODS
The possibility to prevent nucleus pulposus-induced functional and structural nerve root injury by selective tumor necrosis factor-alpha inhibition was assessed in an experimental model in the pig spine.
OBJECTIVE
The objective of the study was to evaluate the role of tumor necrosis
Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study.
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METHODS
Prospective randomized trial.
OBJECTIVE
To examine the effect of the tumor necrosis factor alpha (TNF-α) inhibitor, etanercept, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar spinal stenosis.
BACKGROUND
TNF-α is thought to play a crucial role in
Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica.
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METHODS
An open-label study was conducted.
OBJECTIVE
To evaluate the efficacy and safety of infliximab, a monoclonal chimeric antibody, against tumor necrosis factor-alpha (TNFalpha) for the treatment of severe sciatica.
BACKGROUND
Evidence from animal studies indicates that TNFalpha plays a role in
A systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica.
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OBJECTIVE
Systematic review comparing biological agents, targeting tumour necrosis factor α, for sciatica with placebo and alternative interventions.
METHODS
We searched 21 electronic databases and bibliographies of included studies. We included randomised controlled trials (RCTs), non-RCTs and
Clinical significance of tumor necrosis factor-α inhibitors in the treatment of sciatica: a systematic review and meta-analysis.
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OBJECTIVE
Currently, no satisfactory treatment is available for sciatica caused by herniated discs and/or spinal stenosis. The objective of this study is to assess the value of tumor necrosis factor (TNF)-α inhibitors in the treatment of sciatica.
METHODS
Without language restrictions, we searched
[Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?].
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The domain of sciatica is at the edge of a mini revolution. For ten years evidence have been accumulating in favour of a local inflammation rather than a pathology resulling only from a nerve compression. This hypothesis has first been strengthened by the discovery of inflammatory mediators in human
[Sciatica as a sign of hip disorder with a review of the diagnosis of aseptic necrosis of the femoral head].
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Comment on Williams NH, et al.: a systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica (Eur Spine J, 2013;22(9):1921-35).
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Can sciatica induced by disc herniation be treated with tumor necrosis factor alpha blockade?
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Answer to the Letter to the Editor of Gui-Tao Li et al. concerning: "A systematic review and meta-analysis of biological treatments targeting tumour necrosis factor α for sciatica" by Williams NH, Lewis R, Din NU, Matar HE, Fitzsimmons D, Phillips CJ, Sutton A, Burton K, Hendry M, Nafees S, Wilkinson C (2013) Eur Spine J; 22:1921-1935.
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Salvage operation for persistent low back pain and sciatica induced by percutaneous laser disc decompression performed at outside institution: correlation of magnetic resonance imaging and intraoperative and pathological findings.
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OBJECTIVE
We identified several problems associated with percutaneous lumbar disc decompression (PLDD) based on a study of patients who required salvage operations for complications after undergoing PLDD at an outside institution.
BACKGROUND
PLDD has been performed as a new treatment for
Inflammatory biomarkers in patients with sciatica: a systematic review.
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A Comparison of the Efficacy and Tolerability of the Treatments for Sciatica: A Network Meta-Analysis.
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BACKGROUND
There remains a lack of a systematic summary of the efficacy and safety of various medicines for sciatica, and discrepancies among these exist.
OBJECTIVE
The aim of this study is to comprehensively assess the efficacy of and tolerance to several medical options for the treatment of
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