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[Effect of dibunol on lipid peroxidation and alpha-tocopherol level in the rat heart in acute hemorrhage].

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The authors studied the effect of a single injection of dibunol in a dose of 120 mg/kg on lipid peroxidation (LPO) and alpha-tocopherol (TP) level in the heart muscle in acute blood loss. The LPO products and alpha-tocopherol level were determined simultaneously in a heart homogenate 2 hours after

[Pathogenetic bases of the use alpha-tocopherol and emoxypin in acute hemorrhage].

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The accumulation of lipid peroxidation (LP) products and decrease of alpha-tocopherol (TP) content were demonstrable in the heart, lungs, kidneys and liver after acute blood loss. Injection of TP acetate inhibited LP and raised the content of endogenous TP in the heart, lungs and liver. The

[The effect of dibunol on lipid peroxidation and the alpha-tocopherol level in the lungs of rats with acute blood loss].

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Experiments on linear male rats were made to study the pathophysiological mechanism of the synthetic antioxidant dibunol on the levels of primary and end products of lipid peroxidation (LPO) and of alpha-tocopherol (TP) in the lungs in acute hemorrhage. Dibunol in a dose of 120 mg/kg injected 5 min

Protective effect of vitamin E (DL-alpha-tocopherol) against intraventricular haemorrhage in premature babies.

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Forty four babies, of less than 32 weeks' gestation, were either randomly given 25 mg/kg vitamin E (DL-alpha-tocopherol acetate) intramuscularly after birth (day 0) and on days 1, 2, and 3 or served as controls. Frequent real time ultrasound examinations of the brain were made in each baby during

Retinal hemorrhage in retinopathy of prematurity associated with tocopherol treatment.

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Two hundred eighty-seven infants were enrolled in a double masked, randomized, placebo controlled trial of early parenteral tocopherol given from day one. Among the 232 survivors with ophthalmologic follow-up, retinal hemorrhages occurred more frequently in the tocopherol group (16/111; 14.4%) than

Hemorrhagic toxicity of d-alpha-tocopherol in the rat.

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When male Sprague-Dawley rats were administered d-alpha-tocopherol and butylated hydroxytoluene in the diet or intraperitoneally for 7 days, prolongations of prothrombin time and partial thromboplastin time were observed in those given both chemicals by both routes in a dose-dependent manner.

Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.

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Antioxidants occasionally have become prooxidants when a large amount was ingested. The haemorrhagic toxicity of butylated hydroxytoluene, a synthetic antioxidant, may involve such a mechanism. This study investigated whether haemorrhage is induced by overdoses of tocopherols, beta-carotene,

Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid.

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Alpha-tocopherol (vitamin E) may play a role in the treatment of arterial thromboembolic disease, possibly by inhibiting platelet aggregation. Thus far, no clinical evidence exists for this effect. The objective of this study was to assess the effect of alpha-tocopherol supplementation on gingival

[Effect of alpha-tocopherol on lipid peroxidation in the liver in acute blood loss].

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The effect of single administration of alpha-tocopherol at a dose of 50 mg/kg on lipid peroxidation, content of alpha-tocopherol in liver tissue and on the activities of some enzymes in rat serum was studied under conditions of acute blood loss. The rate of lipid peroxidation in liver tissue and

Cryptogenic Intracranial Hemorrhagic Strokes Associated with Hypervitaminosis E and Acutely Elevated α-Tocopherol Levels.

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Up to 41% of intracerebral hemorrhages (ICH) are considered cryptogenic despite a thorough investigation to determine etiology. Certain over-the-counter supplements may increase proclivity to bleeding, and we hypothesize that specifically vitamin E may have an association with ICH and

[Effect of sodium selenite and alpha-tocopherol on the microcirculation in massive blood loss in dogs].

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Effect of little doses of sodium selenite combined with alpha-tocopherol on microcirculation was studied in experimental bloodletting in dogs. It was established that more rapid recovery, as compared to control, of blood flow in the visceral basin and more rapid elevation of arterial blood pressure

[THE TOCOPHEROL CONTENT OF THE SERUM AND ERYTHROCYTES OF RABBITS DURING ANEMIA DUE TO BLOOD LOSS].

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Effect of intramuscular vitamin E on mortality and intracranial hemorrhage in neonates of 1000 grams or less.

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A randomized, double-blind study to determine the effect of intramuscular vitamin E on mortality and intracranial hemorrhage (ICH) was performed. One hundred forty-nine neonates with birth weights less than or equal to 1000 g and less than or equal to 24 hours of age were grouped by weight (501 to

Interaction between and impact of IL-6 genotype and alpha-tocopherol levels on periodontal condition in aging individuals

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Background and objectives: Few studies have assessed the possible interaction between and impact of IL-6 variants and serum α-tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between IL-6

Synergism of Helicobacter pylori infection and stress on the augmentation of gastric mucosal damage and its prevention with alpha-tocopherol.

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Despite evidence that Helicobacter pylori (H. pylori) infection is closely associated with stress in gastric ulcer patients, the underlying mechanism why ulcer recurrence after stress is augmented especially in patients with H. pylori remains unknown. In this study, we found that oxidative stress

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