In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Adams; Christopher M.

Kunkel; Steven D.

Suneja; Manish

Welsh; Michael

UNIVERSITY OF IOWA RESEARCH FOUNDATION

THE UNITED STATES OF AMERICA AS REPRESENTED BY VETERANS AFFAIRS

Methods for inhibiting muscle atrophy

The topical use of ursolic acid compounds to alter the lipid content of mammalian skin is disclosed. The compounds can be encapsulated in liposomes and administered in this form to the skin in, for example, a lotion or a gel. The compounds are effective in, among other things, reducing the effects of aging, photoaging, and skin atrophy, including skin atrophy resulting from the topical use of retinoids and/or steroids. Compositions comprising a ursolic acid compound in combination with another therapeutically active topical compounds, such as, a retinoid or a steroid, are also disclosed.

Applied Genetics Incorporated Dermatics

Compositions and methods for modification of skin lipid content

ursolic acid

atrophy

ursolic acid/atrophy

Methods for inhibiting muscle atrophy

Compositions and methods for modification of skin lipid content

Најкомплетната база на податоци за лековити билки поддржана од науката