Cyclic octapeptides of the formula ##STR1## in which Aaa represents a radical of a straight-chained .alpha.,.omega.-diaminoalkanoic acid having from 4 to 7 carbon atoms,trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom, which carries a halogen atom in the indole nucleus,Ac.sub.A represents an acyl radical Ac of an optionally substituted carboxylic acid which is positioned at the .omega.-amino group, or represents an amidino group or hydrogen, andAc.sub.B represents an acyl radical Ac.sup.1 of an amino acid or of an oligopeptide which is positioned at the .epsilon.-amino group, or, preferably, represents hydrogen,as well as physiologically tolerable salts and therapeutically acceptable complexes thereof can be used as antidiabetics and for the treatment of gastro-intestinal bleeding in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by the cyclization of corresponding linear peptides.

Ciba-Geigy Corporation

Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use

Acylpeptides derived from somatostatin or from a derivative thereof having analogous action, in which the amino acids sequence is modified by omitting individual amino acids and/or by exchanging them for other amino acids, and in which the .epsilon.-amino group of the lysine residue in the 9-position, and optionally also the .epsilon.-amino group of the lysine residue in the 4-position and/or the N-terminal .alpha.-amino group carries the acyl radical of an optionally substituted alkanecarboxylic acid, and salts and complexes thereof can be used as antidiabetics and/or for combating gastrointestinal bleeding. They are manufactured by conventional methods of peptide chemistry.

antidiabetic/hemorrhage

Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use

Acylpeptides

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