Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Stilbene analogs and methods of treating cancer

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: ##STR00001## wherein R.sup.a, R.sup.b, R.sub.4, R.sub.6, R.sub.7, R.sub.9 and R.sub.10 are all H; R.sub.2 and R.sub.3 are independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR.sub.11R.sub.12, NR.sub.11CO(R.sub.13), NR.sub.11COO(R.sub.13) or NR.sub.11CONR.sub.12R.sub.13; R.sub.11, R.sub.12 and R.sub.13, are independently, H, alkyl, aryl, heteroaryl or a fluorine; R.sub.8 is NR.sup.CR.sup.dZ wherein R.sup.c is H, alkyl, alkoxy, aryl or heteroaryl, R.sup.d is an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen; and R.sub.1 and R.sub.5 are halogen.

stilbene/breast neoplasms

Stilbene analogs and methods of treating cancer

Stilbene analogs and methods of treating cancer

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