Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis
Sleutelwoorden
Abstract
Omschrijving
Periodontal disease is one of the most common diseases in humans and is responsible for most of the tooth loss in adults. World health Organisation report of 2005 described that the global problem persisted with the worldwide oral diseases such as dental caries, periodontal disease, tooth loss, oral mucosal lesions and oro-pharyngeal cancer. According to a local study the prevalence of periodontitis is found to be more in males of older age group and more in rural areas owing to the lack of awareness of importance of oral hygiene.
Apart from various conventional treatment option for periodontitis a number of herbal medicinal intervention have been used for its treatment. Plant extracts and herbs that have been used previously used for periodontal therapy include Salvadora persica, Arnica Montana and Hamamelis virginiana which have been shown to exhibit antibacterial activity against periodonto-pathic bacteria. Phytomedicines (Medicines derived from herbal plants) like indian gum arabic, aloe vera, nim, carvacrol, garlic, wild coffee and propolis resin have been used in dentistry as anti-inflammatory, antibiotics, analgesic and hypnotic agents. Propolis resin, guava and triphala have been also been used for the treatment of periodontitis
Datums
| Laatst geverifieerd: | 07/31/2017 |
| Eerste ingediend: | 08/28/2017 |
| Geschatte inschrijving ingediend: | 08/30/2017 |
| Eerst geplaatst: | 08/31/2017 |
| Laatste update ingediend: | 08/30/2017 |
| Laatste update geplaatst: | 08/31/2017 |
| Werkelijke startdatum van het onderzoek: | 09/10/2017 |
| Geschatte primaire voltooiingsdatum: | 03/10/2018 |
| Geschatte voltooiingsdatum van het onderzoek: | 04/10/2018 |
Conditie of ziekte
Interventie / behandeling
Drug: Nigella Sativa
Drug: Normal Saline
Fase
Armgroepen
| Arm | Interventie / behandeling |
|---|---|
| Placebo Comparator: Normal Saline The group contains healthy individuals with chronic periodontitis who will receive Normal Saline as placebo | Drug: Normal Saline The individuals will apply 55 drops of Normal saline on gingivae twice daily for two weeks |
| Experimental: Nigella Sativa The group contains healthy individuals with chronic periodontitis who will receive Nigella sativa Oil as intervention | Drug: Nigella Sativa The individuals will apply 55 drops of Nigella sativa Oil on gingivae twice daily for two weeks |
Geschiktheidscriteria
| Leeftijden die in aanmerking komen voor studie | 19 Years Naar 19 Years |
| Geslachten die in aanmerking komen voor studie | All |
| Accepteert gezonde vrijwilligers | Ja |
| Criteria | Inclusion Criteria: - Male and female healthy individual - Individuals diagnosed with chronic periodontitis according to the WHO criteria. - Age 19 to 40 years. Exclusion Criteria: - Patients with gingivitis only. - Patients using tobacco products and alcohol. - Underlying systemic pathology such as diabetes mellitus, cardiovascular disease, arthritis etc. - Oral mucosal pre-neoplastic lesions (leukoplakia, erthroplakia, lichen planus) and oral carcinomas. - Obese patients. - Pregnant females. - Xerostomia. - Previous history of radiotherapy or chemotherapy. - Positive history of oral prophylactic procedures (mouthwashes and antibiotics). - Positive history of any periodontal treatment during last 6 months. - Positive antibiotic therapy history within last month of study. |
Resultaat
Primaire uitkomstmaten
1. Levels of IL 1-Beta and MMP-8 [2 weeks]
