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Cancer Research and Treatment 2015-Jul

A Randomized Phase II Trial of Capecitabine Plus Vinorelbine Followed by Docetaxel Versus Adriamycin Plus Cyclophosphamide Followed by Docetaxel as Neoadjuvant Chemotherapy for Breast Cancer.

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Changhoon Yoo
Sung-Bae Kim
Jin-Hee Ahn
Jeong Eun Kim
Kyung Hae Jung
Gyung-Yub Gong
Byung-Ho Son
Sei-Hyun Ahn
Seung Do Ahn
Hak-Hee Kim

Sleutelwoorden

Abstract

OBJECTIVE

Given the promising activity of capecitabine and vinorelbine in metastatic breast cancer, this randomized phase II trial evaluated the efficacy and safety of this combination as neoadjuvant chemotherapy in breast cancer.

METHODS

Patients with operable breast cancer (n=75) were randomly assigned to receive either four cycles of adriamycin 60 mg/m(2) plus cyclophosphamide 600 mg/m(2) every 3 weeks followed by four cycles of docetaxel 75 mg/m(2) every 3 weeks (AC-D) or four cycles of capecitabine 2,000 mg/m(2) (day 1-14) plus vinorelbine 25 mg/m(2) (days 1 and 8) every 3 weeks followed by four cycles of docetaxel 75 mg/m(2) (CV-D). The primary endpoint was pathologic complete response (pCR) in the primary breast (ypT0/is).

RESULTS

Most patients (84%) had locally advanced (n=41) or inflammatory breast cancer (n=22). pCR rates in the primary breast were 15% (95% confidence interval [CI], 7% to 30%) and 11% (95% CI, 4% to 26%) in the AC-D and CV-D groups, respectively. The overall response rates and 5-year progression-free survival rates in the AC-D and CV-D groups were 62% and 64%, and 51.3% (95% CI, 34.6% to 68.0%) and 30.2% (95% CI, 13.3% to 47.1%), respectively. Although both regimens were well tolerated, CV-D showed less frequent grade 3-4 neutropenia and vomiting than AC-D, whereas manageable diarrhea and hand-foot syndrome were more common in the CV-D group.

CONCLUSIONS

CV-D is a feasible and active non-anthracycline-based neoadjuvant chemotherapy regimen for breast cancer.

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