Bioscience, Biotechnology and Biochemistry 2004-Sep
Effects of green tea polyphenol on cognitive and acetylcholinesterase activities.
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Sleutelwoorden
Abstract
The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration of TP significantly reversed scopolamine-induced retention deficits in both step-through passive avoidance and spontaneous alternation behavior tasks. Furthermore, TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.
