Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook.

OBJECTIVE

To evaluate anti convulsant effect of aerial parts of Phyllanthus longiflorus (PHL).

METHODS

Methanol extract of aerial parts of PHL (MPHL) was prepared by continuous hot extraction method using Soxhlet apparatus. MPHL at the doses 100, 200 and 400 mg/kg were administered to male albino mice by oral route and the activity was assessed against maximal electro shock (MES) and pentylene tetrazole (PTZ) induced seizure. Abolition of hind limb extension and onset of clonic convulsion were taken as a measure of MES and PTZ induced convulsion respectively.

RESULTS

MPHL reduced the duration of extensor phase of convulsion in MES test by 62.5% (at 400 mg/kg) and also delayed the onset of clonic phase of convulsion in PTZ test by 50.7% (at 400 mg/kg). The activity was significant (p < 0.01) and comparable to the reference drug diazepam (2 mg/kg).

CONCLUSIONS

Results suggest that aerial parts of Phyllanthus longiflorus are useful in the management of convulsion.