[The production of the tumor necrosis factor in an experimental staphylococcal infection].

The paper deals with the study of production of tumour necrosis factor (TNF), the key mediator of inflammation and immune responses of the organism, under experimental and staphylococcus infection (Staphylococcus aureus, st. 209) on mice of C57B16 line. It is established that staphylococcus infection of animals lead to TNF induction. Dynamics of this cytokinin synthesis by peritoneal macrophages and splenocytes under the infection of mice with S. aureus in different doses differed in time and as to absolute values. In animals infected by staphylococcus in a dose of LD30 the TNF production was high as compared to the control for 72 h after the infection and was normalized on the 4-6th day of the experiment. When using staphylococcus in a dose of LD50, spontaneous production of this cytokinin was higher than that in the control for the whole period of observation.