Shorea roxburghii leaves extract ameliorates hyperglycemia induced abnormalities in high fat/fructose and streptozotocin induced diabetic rats.

This study investigated the hypoglycemic effect of the methanol extract from Shorea roxburghii leaves (SRL) in high fat diet/high fructose (HFDHF) and streptozotocin (STZ) induced type 2 diabetes mellitus (T2DM) in rats as well as evaluating its ameliorative potentials in altered biochemical and hematological parameters in the treated rats. T2DM was induced in Sprague Dawley (SD) rats by feeding with HFDHF for 4 weeks and administering STZ (35 mg/kg, i.p.) Diabetic rats were given SRL extract at doses of 100 and 400 mg/kg for 30 days. The food and water intake were monitored on a daily basis, while the fasting blood glucose (FBG) levels and body weight were measured weekly. Biochemical and hematological parameters as well as histopathological studies of the pancreas were also evaluated. SRL significantly decreased FBG and improved the body weight, food and water intake of treated diabetic rats. Furthermore, biochemical and hematological parameters including liver and kidney function enzymes, lipid profiles, white blood and red blood cells parameters were markedly ameliorated by SRL. Histopathological analyses of the pancreas indicated reconstitution of β-cells architecture in SRL treated rats. The results from this study suggests that SRL have antidiabetic potentials and can be considered for the treatment of T2DM Highlights.