antidepressants/necrotisch

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Safety and Efficacy of Tramadol in COVID-19 Egyptian Patients

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Background and Rationale: T cells play a critical role in antiviral immunity, their level was dramatically reduced in COVID-19 patients. There is a negative correlation between T cell numbers and cytokines serum level in COVID-19 patients. In those patients, there is up-regulation of inflammatory

Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)

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Stress-related disorders, such as depression, are some of the most disabling human illnesses worldwide. Most currently available treatments for depression target neurochemical or neurobiological mechanisms identified retrospectively following discovery of the drug's initial antidepressant efficacy.

A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder

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Bipolar Disorder is a chronic disabling psychiatric disorder characterized by recurrent episodes of mania or hypomania and depression. Bipolar Disorder can be separated into bipolar I and bipolar II disorders with bipolar I disorder characterizing individuals who have episodes of mania and

The Role of PKC Activation in the Immune-inflammatory Mechanism of Major Depressive Depression

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This is a randomized, double blind, placebo-controlled antidepressant augmentation trial. All participants are randomly divided into 3 groups treated orally with "escitalopram + golimumab" (N = 60), "escitalopram + calcium tablet" (N = 60) or "escitalopram +placebo" (N = 60).

Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression

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Repetitive transcranial magnetic stimulation (rTMS) is prescribed as first-line treatment for patients with Major Depressive Disorder. rTMS is safe, tolerable and non-invasive neurostimulation procedure. rTMS is characterized by an advantage in comparison to traditional pharmacotherapy in the sense

The Role of Inflammatory Processes in Development and Treatment of Depression

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The study investigates the influence of inflammatory processes on the development and the course of uni- and bipolar depression. It is assumed, that the concentrations of certain inflammatory proteins have an influence on the development of depression, its clinical severity, the response to

The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers

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Current antidepressant treatments, which largely target monoamine pathways, are efficacious in treating many aspects of major depression, however it is estimated that more than 30% of depressed patients fail to respond to standard antidepressant medications. Thus, there is a strong clinical need to

Evaluation of Schemes of Administration of Intravenous Ketamine in Depression

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1. Background 1.1 Major depressive disorder (MDD) MDD is a clinical syndrome characterized by the presence of low modo, anhedonia, appetite and weight changes, sleep disturbances, psychomotor alterations, fatigue, guilt and low self-esteem, ideas related to death or suicide, and concentration

Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder

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Major depressive disorder (MDD) is among the leading causes of overall global disease burden. Much of this burden derives from the fact that currently available pharmacologic modalities suffer from important shortcomings, including limited efficacy, delayed onset of action, and significant side

Scrambler Trial for Pain in NMOSD

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Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system that disproportionately affects non-Caucasians and females,1,2 and has a worldwide prevalence estimated to be 0.52 to 4.4/100,000.3 NMOSD preferentially causes recurrent inflammatory attacks in

Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation

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1. Background Major depressive disorder (MDD) is a complex and long-term illness that involves marked disabilities in affected patients. It has been one of the leading causes of global burden of disease, especially in the middle-age groups (GBD Lancet 2016; 388:1603-58). It is also a common

Inflammation-Induced CNS Glutamate Changes in Depression

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This study aims to test the hypothesis that increased inflammation causes increased basal ganglia glutamate and consequently anhedonia and psychomotor retardation in patients with major depressive disorder (MDD). Excessive inflammation and glutamate excitotoxicity are two pathways that have received

Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach

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This study will evaluate the anti-inflammatory effects and antidepressant efficacy and tolerability of EPA versus placebo in the treatment of MDD. The study design is a randomized, placebo-controlled, double-blind parallel-group dose-finding 12 week outpatient clinical trial. The study population

Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial

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Major depressive disorder is associated with significant morbidity and mortality. According to the WHO, depression is the leading cause of disability worldwide in terms of years lost due to disability [1]. Although depressive symptoms are amenable to antidepressant treatment, a high proportion of

Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients

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To explore the use of ketamine as a potential rapidly-acting antidepressant (RAA) for Emergency Department (ED) patients with major depressive disorder (MDD). Investigators will conduct a randomized controlled study to evaluate the rapidity and persistence of antidepressant effects of a single

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