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benzoquinone/sarcoom
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Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice.
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Compounds having the basic structure N-(R)-substituted ring-substituted 4-iminocyclohexadienone have been synthesized and tested as antitumor agents against the ascitic sarcoma 180 tumor in Swiss mice. Among these compounds, the dimethylindoanilines [R = 4-(CH3)2NC6H4] are most stable in water at pH
[ON THE EFFECT OF 2,3,5-TRIS(ETHYLENEIMINO)-P-BENZOQUINONE (TRENIMON) ON THE METABOLISM OF JENSEN SARCOMA].
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[THE EFFECTS OF 2,3,5-TRIS-ETHYLENIMINO-1,4-BENZOQUINONE ON OXYGEN-CONSUMING REACTIONS IN YOSHIDA ASCITES SARCOMA CELLS].
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The in vitro trypanocidal activity of N-substituted p-benzoquinone imines: assessment of biochemical structure-activity relationships using the Hansch approach.
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It has previously been found that naphthoquinones can potentiate the rate of hydrogen peroxide production by mitochondrial preparations of Trypanosoma brucei brucei and that organisms treated with naphthoquinones are more susceptible to lysis, especially in the presence of compounds such as heme,
The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.
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FAK is a nonreceptor tyrosine kinase involved in adhesion-mediated signal transduction whose level of expression is related to the invasiveness of malignant tumors. In seeking strategies to downregulate FAK, we treated various cell lines in vitro with the benzoquinone ansamycin geldanamycin (GA)
Synthesis and antitumour activity of the Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone) and analogues.
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Cancer is a serious worldwide health threat, killing almost seven million people per year. Quinones are an important class of antitumour agents that are activated by tumour hypoxia. Primin (2-methoxy-6-n-pentyl-1,4-benzo-quinone), a naturally-occurring product obtained from Primula obconica
Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
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BACKGROUND
Despite substantial improvements in childhood cancer survival, drug resistance remains problematic for several paediatric tumour types. The urgent need to access novel agents to treat drug-resistant disease should be expedited by pre-clinical evaluation of paediatric tumour models during
Antitumor effect and structure-activity relationship of asterriquinone analogs.
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Asterriquinone (ARQ), a metabolic product from Aspergillus terreus IFO 6123, showed an inhibitory effect on some transplantable animal tumors, Ehrlich carcinoma, ascites hepatoma AH13 and mouse P388 leukemia, but had little or no effect on Yoshida sarcoma, ascites hepatoma AH109A and mouse L1210
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