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12 resultaten
Biphenyl derivative and uses thereof
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TECHNICAL FIELD
The present invention belongs to the field of pharmaceutical technology and relates to a novel use of a drug, and specifically to a novel use of biphenyl derivatives in the manufacture of a medicament for the treatment and/or prevention of ischemic stroke.
BACKGROUND
In recent years,
Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis
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BACKGROUND OF THE INVENTION
The present invention relates to novel biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorine-substituted biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically
Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorine-substituted biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically
Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
The present invention provides pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl[benzimidazole-7-carboxylat e having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which are of practical value in clinical use as therapeutic
1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-c arboxylate and compositions and methods of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
In a first aspect of the invention there is provided 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate, including certain stable forms as well as pharmaceutically acceptable salts, which have
Potent
Substituted biphenyl derivatives
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The invention relates to compounds of the formula I ##STR2##
in which: R.sup.1 is: phenyl or naphthyl, which is substituted by --C(.dbd.NH)NH.sub.2, that can also be monosubstituted by --COA, --CO--[C(R.sup.7).sub.2 ].sub.n -Ar', --COOA, --OR.sup.7, --OCOA, --OCO--[C(R.sup.7).sub.2 ].sub.n -Ar' or
7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
Tetrahydro-naphthalene derivatives
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DETAILED DESCRIPTION OF INVENTION
1. Technical Field
The present invention relates to a tetrahydro-naphthalene derivative which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivative of the present invention has vanilloid receptor (VR) antagonistic
Substituted triazoles as angiotensin II inhibitors
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FIELD OF THE INVENTION
This invention relates to novel compounds of the following formulae: ##STR1##
The invention also relates to pharmaceutical compositions comprising a compound of the invention as the active ingredient, a method of treating a physiological condition in mammals that is mediated
Benzimidazole derivative compositions and medical use thereof
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SUMMARY OF THE INVENTION
The present invention provides 1-acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which is of practical value in clinical use as
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