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Role of TLR4 receptor polymorphisms in Boutonneuse fever.

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The genetics of the interaction between host and microbes plays an essential role in the survival of the individual and attainment of longevity. The activation of toll-like receptor (TLR)4 plays a key role in natural and clonotypic immune responses. We evaluated whether TLR4 genotype is a component

[Mediterranean spotted fever. A case report and review of literature].

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A patient was documented as having mediterranean spotted fever by indirect immunofluorescence antibody test and inoculation of the patient's blood into the yolk sac of embryonated hen egg. In general, the infection of rickettsia conorii is caused by bite of infected tick. The infection in this case,

Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever.

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The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received

Mediterranean-spotted fever: clinical and laboratory characteristics of 34 children in Oran (Algeria).

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BACKGROUND Mediterranean-spotted fever (MSF) is endemic in the Mediterranean basin. The aim of our study is to describe clinical and laboratory characteristics of MSF in Algeria. METHODS Retrospective study of 34 children suffering from MSF hospitalized from 2002 to 2005. Diagnosis and outcome data

Boutonneuse fever and climate variability.

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Researchers have long appreciated the role of climate in vector-borne diseases, including the resurgence of boutonneuse fever (BF). Portugal usually is classified as having temperate Mediterranean climate. In this new century, in analyzing the data from the Meteorology Institute, this pattern has

New trends in Mediterranean spotted fever.

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Mediterranean Spotted Fever is a disease caused by Rickettsia conorii. It is endemic to the Mediterranean area, where, for the last few years, the number of cases has increased, possibly due, in part, to climatic factors. The main clinical aspects of a prospective series of 246 cases diagnosed from

Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015.

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Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii and transmitted by Rhipicephalus sanguineus sensu lato. The aim of this study is to understand the epidemiology and trends regarding the disease in Spain, based on notifications to the Spanish National

Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever.

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The serum levels of beta2-microglobulin (beta2-M), soluble HLA class I antigen (sHLA-I), soluble CD4 (sCD4) and CD8 (sCD8) were studied in 98 Sicilian patients with Boutonneuse fever (BF). In different stages of infection all markers were significantly increased in sera from Sicilian patients with

[Mediterranean spotted fever in paediatric and adult patients: two clinical aspects of the same disease].

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Mediterranean Spotted Fever is an acute febrile disease caused by Rickettsia conorii and transmitted to humans by the brown dog tick Rhipicephalus sanguineus. Nearly 400 cases are reported every year in Sicily, mainly from June to September. The aim of this study is to compare the clinical and

Use of western blot to analyze the reactivity of sera from patients with Mediterranean spotted fever.

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The reactivity of antigenic components of Rickettsia conorii with sequentially obtained sera from 20 adult Spanish patients with Mediterranean spotted fever was analyzed by Western blot. The major rickettsial antigens reacting with the serum samples corresponded to molecular weights of 135 and 115

[Enzymatic parameters in boutonneuse fever. II. Behavior and significance of lactic dehydrogenase].

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Serum levels of Lactic dehydrogenase (LDH) were determined at weekly intervals, in 52 patients with Boutonneuse Fever: 33 adults (23 uncomplicated and 10 complicated cases) and 19 children (no complication occurred in these patients). In the first week of illness, LDH was increased in 86 and 100% of

[Serology of Mediterranean boutonneuse fever. Kinetics of antibodies detected by 3 methods: indirect immunofluorescence, indirect hemagglutination and latex agglutination].

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The purpose of this work was to determine the kinetics of antibodies in mediterranean spotted fever as determined by three serologic methods: indirect fluorescent antibody test, latex agglutination test and indirect hemagglutination test. No difference was noticed in the early kinetics but after 6

[Determination of antibody kinetics in Mediterranean spotted fever using the Weil-Felix agglutination test, complement fixation and indirect immunofluorescence].

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The kinetics of antibodies in human cases of Mediterranean spotted fever was studied by applying Weil-Felix (WF) agglutination with Proteus OX antigens, complement fixation (CF) and indirect immunofluorescence (IF) tests with Rickettsia conorri antigen to 46 sera from 21 patients. The kinetics of

Mediterranean Spotted Fever in Travelers from the United States.

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Background: We wish to increase awareness by U.S. physicians of the clinical manifestations and diagnosis of Mediterranean spotted fever (MSF), and to determine the incidence of MSF among travelers returning to the United States from endemic areas. Methods: We report a case of a 56-year-old female

Western blot as a seroepidemiologic tool for detecting foci of Mediterranean spotted fever (MSF).

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We conducted a serosurvey on Mediterranean spotted fever (MSF), in a nonendemic area using western blot and microimmunofluorescence. Among 262 tested sera, 53 were positive by micro-immunofluorescence at a titer of 50. When 48 positive sera were western blot tested, 15 did not exhibited any

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