cataract/obesitas

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The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different class I gene products.

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We have studied with a series of monoclonal antibodies and restriction fragment analysis the K, D, and class II region of the major histocompatibility complex of the non-obese diabetic mouse in comparison with its sister strains, the non-obese non-diabetic and cataract Shionogi mouse. (1) K region:

RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains.

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The non-obese diabetic (NOD) mouse strain which spontaneously develops diabetes is a model for human Type 1 (insulin-dependent) diabetes mellitus. At least one of several genes controlling diabetes in the NOD mouse has been mapped to the MHC. Although previous experiments have implicated the MHC

Relation of age-related cataract with obesity and obesity genes in an Asian population.

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Obesity shows an inconsistent association with cataract. Causality has not been established. Polymorphisms at the fat mass- and obesity-associated (FTO) locus are associated with obesity and offer an opportunity to examine the obesity-cataract association using a mendelian randomization approach.

Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study.

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The obesity-cataract association has been inconsistently reported. The fat mass and obesity-related (FTO) single-nucleotide polymorphism (SNP) rs9939609 is a major SNP associated with obesity and has been used as an instrumental variable for obesity in a Mendelian randomization (MR)

Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol.

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Epidemiological studies have reported an association between obesity and increased incidence of ocular complications including cataract, yet the underlying biochemical and molecular mechanisms remained unclear. Previously we had demonstrated accumulation of sorbitol in the lens of obese rats

Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats.

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OBJECTIVE Obesity is a major public health problem worldwide, and of late, epidemiological studies indicate a preponderance of cataracts under obesity conditions. Although cataract is a multifactorial disorder and various biochemical mechanisms have been proposed, the influence of obesity on

Association between cataract and the degree of obesity.

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OBJECTIVE To investigate the association between the degree of obesity and cataract. METHODS We examined 3248 subjects (1421 men and 1827 women) aged 50 years and older who did not have a previous cataract operation. Data were derived from the fourth Korea National Health and Nutrition Examination

Diabetes, hypertension, and central obesity as cataract risk factors in a black population. The Barbados Eye Study.

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OBJECTIVE The increased cataract prevalence of black populations, especially of cortical cataract, remains unexplained. The authors evaluate the relationships of diabetes, hypertension, and obesity patterns to lens opacities, by age, among 4314 black participants in the Barbados Eye

The Gender-Dependent Association between Obesity and Age-Related Cataracts in Middle-Aged Korean Adults.

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The aim of this study was to investigate the association of central and abdominal obesity with the prevalence of cataracts in a middle-aged Korean population. This retrospective cross-sectional study was based on the data collected from the Korea National Health and Nutrition Examination Survey

Overweight, obesity, and age-related cataract: a meta-analysis.

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OBJECTIVE To examine the longitudinal association of overweight/obesity with age-related cataract. METHODS A systematic review of the literature was performed using PubMed and Embase from their inception until June 2013 for prospective data on body mass index categories identical or similar to the

Modifications in cataract surgery for the morbidly obese patient.

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We describe a standing phacoemulsification technique (SPT) with the patient in reverse Trendelenburg position (RTP) as a means of performing surgery in morbidly obese patients. These patients have elevated vitreous pressure, leading to a high rate of posterior capsule rupture and vitreous loss. The

Senile cataract and glucose intolerance: the Israel Study of glucose Intolerance Obesity and Hypertension (The Israel GOH Study).

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Association of "senile" cataract (SC) with glucose intolerance (impaired tolerance and diabetes) was assessed by sex and age in a random population sample comprising 930 individuals aged 40-70 yr, who underwent concurrent oral glucose tolerance test and ophthalmoscopy. The eye examination was

Does obesity increase the risk for cataracts?

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A new substrain of the non-obese diabetic mouse which develops cataracts (NOD/Ba/Lop19)

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Cataracts with obesity, small stature, oligophrenia, and acromicria (Prader-Labhart-Willi syndrome).

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