Patients will have tube feeds placed through chamber and evaluate wean from parenteral nutrition

Short Bowel Syndrome

Malabsorption

Tube feeds run across device to digest fats.

Relizorb

Boston Children's Hospital

A 90 Day, Phase 4,Open Labeled Exploratory Study of RELiZORB

A 90 Day, Phase 4, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on Parenteral Nutrition

To determine the effectiveness of the RELiZORB enzyme cartridge on the absorption of enteral nutrition when used daily for a total 90 days of treatment, in pediatric subjects with SBS who are PN dependent, aged 5 years - 18 years, by measuring the change in PN calories from baseline, assessed at days 7, 14, 28, 60, and day 90. Each subject will be on the study for a total of 90 days.

• To determine the effectiveness of the RELiZORB enzyme cartridge on the absorption of enteral nutrition when used daily for a total 90 days of treatment, in pediatric subjects with SBS who are PN dependent, aged 5 years - 18 years, by measuring the change in body weight from baseline, assessed at days 7, 14, 28, 60, and day 90. Each subject will be on the study for a total of 90 days.

Mark Puder

MD, PhD, Professor Pediatric General Surgery

Boston Children’s Hospital

Alcresta Therapeutics, Inc.

1 g/kg intravenous fish oil lipid emulsion (Omegaven) daily, provided starting day of transplant through day 30 or hospital discharge, whichever comes first.

1 g/kg intravenous soybean oil lipid emulsion (SOLE) daily, provided starting day of transplant through day 30 or hospital discharge, whichever comes first.

Hematopoietic Stem Cell Transplantation

Omegaven

Soybean oil lipid emulsion

Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation

Number and type of adverse events, categorized according to NCI Common Toxicity Criteria

Essential fatty acid pane, triene:tetraene ratio

Incidence of serum fasting triglyceride levels > 200 mg/dl

Validated quality of life measure (Peds QL) to measure quality of life

Alexandra N. Carey

Instructor of Pediatrics

Cholestasis

Total Parenteral Nutrition-induced Cholestasis

Therapy with Omegaven® will be initiated and maintained at 1 g/kg/day. It will be infused intravenously through either a central or peripheral catheter in conjunction with parenteral nutrition. If additional non-protein calories are needed, they will be provided as carbohydrates. No other parenteral form of fat emulsion will be used during Omegaven® therapy.The Omegaven® dose may be discontinued if the subject is receiving adequate enteral nutrition to meet metabolic and growth needs.

Rush University Medical Center

Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury

Open Protocol for the Use of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury

Aloka Patel

Associate Professor

Gastrointestinal Neoplasms

Postoperative Complications

low calorie, low nitrogen parenteral nutrition for patient with NRS score 3

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University

Department of General Surgery, Affiliated Hospital of Medical University of Tongji

Department of General Surgery, General Hospital of PLA

The Impact of Low Calorie and Low Nitrogen Parenteral Nutrition Support on the Clinical Outcome of Postoperative Patients

Comparing With Traditional Nitrogen Calorie Parenteral Nutrition Support, the Impact of Low Calorie and Low Nitrogen Intake on the Clinical Outcome of Gastrointestinal Postoperative Patients, Multicentre Post-Marketing Clinical Study

cholestasis/carbohydrate

A 90 Day, Phase 4,Open Labeled Exploratory Study of RELiZORB

Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation

Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury

The Impact of Low Calorie and Low Nitrogen Parenteral Nutrition Support on the Clinical Outcome of Postoperative Patients

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