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ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.

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The ATP-binding cassette (ABC) transporter A subfamily 8 (ABCA8) belongs to the ABCA6-like transporters subgroup, which is distinct from the ABCA1-like subgroup in the ABCA family. The expression and function of the short-size human ABCA8 lacking one of the two ATP-binding domains for ATP

Interaction of cigarette smoke condensate and some of its components with chlorpromazine toxicity on Saccharomyces cerevisiae.

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Chlorpromazine (CPZ) is an antipsychotic phenothiazine which is still commonly prescribed though it causes idiosyncratic toxicity such as cholestasis. CPZ toxicity mechanisms involve oxidative stress among others. Cigarette smoke (CS) causes deleterious effects through diverse mechanisms such as

[Activity of alanine aminopeptidase in blood and in urine of smoking and non-smoking smelters].

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The human body is constantly exposed to xenobiotics. This will include exogenous substances from environmental pollution such as heavy metals and lifestyle such as smoking, which may lead to impaired functioning of many organs. The liver and kidney are the critical organs in the case of a long-term

[Effect of smoking on caffeine elimination by the liver in patients with chronic liver diseases].

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Effect of smoking cigarettes on hepatic metabolizing capacity of caffeine in respect to the extent of liver damage was studied among 46 patients with chronic liver disease and 6 healthy, nonsmoking subjects. The rates of hepatic elimination in cirrhosis (68 +/- 35 ml/min) and chronic extrahepatic

[Postnatal visit: Routine and particularity after complicated pregnancy--Guidelines for clinical practice].

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OBJECTIVE To propose guidelines for clinical practice for routine postnatal visit and after pathological pregnancies. METHODS Bibliographic searches were performed with PubMed and Cochrane databases, and within international guidelines references. RESULTS Postpartum visit should be planned 6 to 8

Influence of pre-, intra- and post-operative parameters of donor liver on the outcome of isolated human hepatocytes.

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The aim of the present study was to analyse, retrospectively on a large panel of patients (149), the influence of the donor liver characteristics on the outcome of human hepatocyte isolation obtained from resected liver biopsies from surgical waste after hepatectomy. Among the pre-operative

Alpha-1 Antitrypsin Deficiency-Mediated Liver Toxicity: Why Do Some Patients Do Poorly? What Do We Know So Far?

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Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disease caused by mutations in the SERPINA1 gene and is associated with a decreased level of circulating alpha-1 antitrypsin (AAT). Among all the known mutations in the SERPINA1 gene, homozygous for the Z allele is well-known to

Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting.

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alpha 1-Antitrypsin (AAT) deficiency, also known as alpha 1-antiprotease inhibitor deficiency, is a disease caused by genetically determined AAT deficiency. It occurs as a result of inheritance of two protease inhibitor (PI) deficiency alleles from the AAT gene locus (designated PI) on chromosomal

Molecular Pathogenesis of Cholangiocarcinoma.

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Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the

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