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Convalescent Plasma Therapy in Severe COVID-19 Infection

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Rationale of the Study Currently no specific treatment is available against COVID-19 infection. Supportive treatment along with concentrated oxygen is the only mean of treatment. Researchers have already opened over 180 clinical trials of potential COVID-19 treatments for recruitment, and nearly 150

Experimental Use of Convalescent Plasma for Passive Immunization in Current COVID-19 Pandemic in Pakistan in 2020

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Passive immunization involves the administration of antibodies against a given agent to a susceptible individual for the purpose of preventing or treating an infectious disease due to that agent. A general principle of passive antibody therapy is that it is more effective when used for prophylaxis

68Ga Citrate PET/MRI for Evaluation of Fever of Unknown Origin (FUO)

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The purpose of this research study is to evaluate a PET tracer (68Ga-Citrate) that can localize the origin of patients diagnosed with fever of unknown origin (FUO) using a PET/MRI scanner. We hope to learn if this can detect FUO better than with the present nuclear imaging standard of care (67Ga

Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib

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The purpose of this study is to determine the immune response from the new Shingrix vaccine in UC patients on tofacitinib monotherapy in comparison to other UC therapies. the investigators plan to determine this by vaccinating IBD patients on (a) tofacitinib monotherapy, (b) anti-TNF monotherapy,

Port Protectors for Prevention of CLABSIs in Respiratory Semi-intensive Care Unit

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The study enrolled patients admitted to RICU and it lasted 18 months. Patients were enrolled when a CVC: 1) was placed during hospitalization in RICU; 2) had already been placed at admittance and patients didn't show signs of systemic inflammatory response syndrome (SIRS) during first 48h from

Changes in the Gut Microbiota of Patients Undergoing Allogeneic Stem Cell Transplantation (COLLECT)

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Documentation of patient is performed by using the web-based survey platform www.ClinicalSurveys.net which was set up by researchers of the University Hospital of Cologne. This survey platform enables an optimal performance in epidemiological, observational, and interventional trials and is

P. Falciparum Resistance to Artemisinin in Vietnam

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3.1 Study Design This study is designed as a randomized open label 42-day follow-up study to evaluate the clinical and parasitological responses after treatment of uncomplicated P.falciparum infections with either AS or DHA-PPQ. Symptomatic patients with P.falciparum mono-infections, fulfilling the

Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters

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METHODS Study Design This double blind randomized controlled trial (RCT) was conducted from July 2012 until July 2014 in the dialysis and transplantation unit of a Brazilian university hospital. The patients were randomly assigned to have their catheter locked with either unfractionated sodium

Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

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The two most important causes of iron overload disease in humans are the iron-loading disorder hereditary hemochromatosis (HC), and transfusional siderosis in patients with chronic hematological diseases like myelodysplastic syndrome (MDS), thalassemia, and leukemia. Hemochromatosis. In HC the

Effect of Filarial Infection on Immune Responses in Latent Tuberculosis

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Tissue-invasive helminth parasites infect close to 500 million people worldwide and are associated with strong T helper (Th)2 responses and regulatory networks that downregulate potentially protective Th1 responses. The two common tissue invasive helminth parasites are Wuchereria bancrofti, that

Sublingual Misoprostol & Isoflurane During Caesarean Section

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Volatile anaesthetics including sevoflurane, desflurane, and isoflurane are often used during general anaesthesia for caesarean delivery. The cost effectiveness of isoflurane anaesthesia1 for caesarean delivery is widely used at many centres including the authors' centre, where general anaesthesia

Oral Rehydration Solution With Zinc and Prebiotics in Acute Diarrhea

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Study Design and Funding Prospective, randomized controlled trial in collaboration with family pediatricians, who care for children up to 14 years of age in the Italian Public Health System. The study protocol was illustrated and discussed during 3 meetings. The research is not funded by any

Enteric Coating as a Factor in Aspirin Resistance

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In a recent study we have shown clear evidence for pharmacokinetic aspirin resistance in healthy volunteers due to poor bioavailability of enteric-coated aspirin. However, it is necessary to confirm that pharmacokinetic resistance is an important factor in aspirin resistance in a patient population

Introduction of Hypo-osmolar ORS for Routine Use

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Study site: The Dhaka and the Matlab Hospitals of ICDDR, B: Centre for Health and Population Research. Duration: Total duration of 15 months that include data collection over a full year to capture seasonal variations in the aetiology of diarrhoea. Sample size: Based on the yearly patient visits it

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