cosmos/phosphatase

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Cosmos 1887: morphology, histochemistry, and vasculature of the growing rat tibia.

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Light microscopy, electron microscopy, and enzyme histochemistry were used to study the effects of spaceflight on metaphyseal and cortical bone of the rat tibia. Cortical cross-sectional area and perimeter were not altered by a 12.5-day spaceflight in 3-month-old male rats. The endosteal osteoblast

The digestive tract of rat after flight in the biosatellite Cosmos 1667.

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From the histochemical investigation carried out on the digestive tract of rats after 7 days space flight in the soviet biosatellite Cosmos 1667 it resulted that neutral and acid glycoproteins diminished slightly in the sublingual gland, stomach, small intestine and the colon. Some intestinal

[Phosphatase activity in the forearm bones of rats after a flight aboard the biosatellite "Cosmos-936"].

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Activities of alkaline and acid phosphatases in ulnar and radial bones of rats flown for 18.5 days aboard Cosmos-936 and kept in a ground-based mock-up were investigated. In both bones activity of acid phosphatase increased significantly and that of alkaline phosphatase decreased 6--10 hours

[Histomorphometric analysis of the bones of rats exposed to "Cosmos-1887" space flight].

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Tibia and lumbar vertebrae of rats sacrificed 2 days after their 13-day space flight on Cosmos-1887 were examined histomorphometrically. It was found that the exposure led to osteoporosis of the primary and secondary spongiosa of tibia proximal metaphyses and early signs of bone reduction in the

[Activity of various liver enzymes in rats following a flight aboard the Cosmos-936 biosatellite].

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After the 18.5-day flight on board the biosatellite Cosmos-936, the activity of 6 glucocorticoid-activated enzymes in the rat liver was investigated. It was found that at R+O activities of tyrosine aminotransferase and tryptophane pyrrolase, as well as fructose-1,6-diphosphatase,

Cosmos 1887 mission overview: effects of microgravity on rat body and adrenal weights and plasma constituents.

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The Cosmos 1887 biosatellite carried 10 male rats and 2 rhesus monkeys on its 12.5-day mission. Upon re-entry the Vostok vehicle overshot the designated landing site, which resulted in fasting of the animals for 42 h, exposure to cage temperatures of 12-15 degrees C, and 2 days delay in death of the

Modifications of the digestive tract in rats submitted to an orbital flight aboard the Soviet satellite Cosmos 1129.

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Investigations carried out on the digestive tract of rats submitted to an 18 1/2-day orbital flight aboard the Soviet biosatellite Cosmos 1129 revealed that flight produces a reduction of the glycoproteins (GP) of the submaxillary glands, gastric mucosa and the goblet cells of the small and large

Histochemical alterations in the digestive tract of rats after 13 days of flight in the "Cosmos 1887" biosatellite.

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In rats recovered after 13 days of cosmic flight a diminution of acid and neutral glycoproteins was observed in the gastric mucosa and proximal segments of the small intestine: the decrease was less evident in the sublingual glands and colon. Leucine aminopeptidase and acid phosphatase in the small

Effects of weightlessness on bone mass and osteoclast number in pregnant rats after a five-day spaceflight (COSMOS 1514).

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Five pregnant growing rats were orbited for 5 days aboard the Soviet COSMOS 1514 biologic satellite. The bone effects of weightlessness were studied and compared to those of five pregnant rats kept in vivarium and five pregnant conditioned rats. Bone histomorphometric studies were performed to

Detection of PHLPP1α/β in human and mouse brain by different anti-PHLPP1 antibodies.

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Pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a member of the serine/threonine family of phosphatases. It has been studied in organs including brain, heart, pancreas, adipose, breast, and prostate. Human PHLPP1 encodes two splice variants - PHLPP1α (~140-150

Alterations in bone forming cells due to reduced weight bearing.

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A reduction in new bone formation occurred as a result of space flight (Cosmos 1129) and in the suspended animal model of Morey-Holton. Our results indicate that alkaline phosphatase activity of the bone forming cells is also reduced under these conditions, and the cells in the diaphysis are more

The action of simulated and true weightlessness on the digestive tract of rats.

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Rats on board the Soviet Cosmos 936 satellite for l8 1/2 days showed a decreased glycoprotein secretion from the salivary mucous glands, stomach and intestine, and an increased leucine aminopeptidase and acid phosphatase content from the small intestine. Grimelius positive cells were activated. One

[Enzymatic activity in the liver and lipogenesis processes in the fatty tissue of rats after a space flight].

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The rats flown aboard Cosmos-782 showed a significant increase in the activity of tyrosine aminotransferase and tryptophan pyrolase, i. e. the enzymes whose activity depends on the corticosterone level. The synchronous rats displayed a small increase in the enzyme activity. The flight and

Human saliva exposure modulates bone cell performance in vitro.

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Various situations encountered by a clinician during the daily routine including surgical periodontitis therapy, dental implant insertion, or tooth extraction involve the contact of saliva with the jaw bone. However, there are only sparse data concerning the influence of saliva on bone cells. Saliva

Electron microscopic and histochemical studies of the mononuclear odontoclast of the human.

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BACKGROUND Osteoclasts and odontoclasts are multinucleated giant cells which resorb hard tissue by the ruffled borders. Recently, the authors reported the presence of a mononuclear osteoclast with a ruffled border in vitro. However, its presence in vivo has not been shown. To demonstrate the

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