cymene/inflammatie

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p-Cymene Modulate Oxidative Stress and Inflammation in Murine Macrophages: Potential Implication in atherosclerosis.

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p-Cymene (p-CYM) is a common chemical used in air fresheners.The study was designed to investigate the molecular effect of p-CYM on macrophages.Macrophages (RAW 264.7) were treated with p-CYM (50 uM/L, 150 uM/L and 250 uM/L) for

p-Cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activation.

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The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory

Improvement of p-cymene antinociceptive and anti-inflammatory effects by inclusion in β-cyclodextrin.

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Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short half-life is a limitation for p-cymene application and several approaches have been used to improve pharmaceutical properties of monoterpenes, including the employment of drug-delivery systems. Here, we used

Evaluation of the anti-inflammatory and antinociceptive properties of p-cymene in mice.

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We attempted to identify the antinociceptive and anti-inflammatory actions of the monoterpene p-cymene. Firstly, behavioural screening was carried out to verify the influence of p-cymene [25, 50, and 100 mg/kg intraperitoneal (i.p.)] on the central nervous system (CNS) activity. The antinociceptive

The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: Evidence for the involvement of opioid system and cytokines.

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BACKGROUND Pain corresponds to the most frequent reason for visits to physicians, and its control by conventional drugs is accompanied by several side effects, making treatment difficult. For this reason, new chemical entities derived from natural products still hold great promise for the future of

p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upkeeping ZO-1 and MUC-2: Role of Antioxidant System and Immunomodulation

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p-Cymene (p-C) and rosmarinic acid (RA) are secondary metabolites that are present in medicinal herbs and Mediterranean spices that have promising anti-inflammatory properties. This study aimed to evaluate their intestinal anti-inflammatory activity in the trinitrobenzene sulphonic

The vasorelaxant effect of p-cymene in rat aorta involves potassium channels.

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The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its

Chemical constituents and anti-inflammatory activity of leaf essential oil of Nigerian grown Chenopodium album L.

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Hydrodistilled leaves of Chenopodiumalbum yielded 0.64 % v/w of essential oil. GC and GC/MS analyses of the oil revealed that the bulk of the oil was constituted by aromatic compounds (60.1 %). The abundant constituents of the oil were: p- cymene (40.9 %), ascaridole (15.5 %), pinane-2-ol (9.9 %),

Acute & Sub-Acute toxicity studies and Pharmacodynamic studies of standardized extract of Trachyspermum ammi (L.) Sprague (Fruits) against chemically induced inflammation in rats

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Introduction: Nowadays the researchers have been attempting to use herbal products as medicines which have proven in many aspects to cause lesser side effects. The fruit part of Trachyspermum ammi (L.) - Ajwain has been an integral part

Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryophyllene on rat sciatic nerve excitability.

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Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Several studies have shown that the EOLs and its constituents have

Nigella Sativa's Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation

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Nigella sativa (NS) has been used for centuries in various inflammatory conditions because of its anti-inflammatory and antioxidant activities. The study aimed to evaluate the anti-inflammatory, antinociceptive and antioxidant activity of Nigella sativa oil (NSO) in two models of acute

In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway.

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OBJECTIVE Terpenes are considered the main components of essential oils and an important source for the identification of novel lead molecules. This study aimed to investigate the in vitro anti-inflammatory activity of L-carveol, L-carvone, and m-cimene (monoterpenes) and of valencene and guaiene

Cymene and Metformin treatment effect on biochemical parameters of male NMRI mice fed with high fat diet.

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BACKGROUND The increasing prevalence of obesity is considered a serious global health threat. Mainly due to change of diet and reduced physical activity, obesity is an important risk factor for chronic diseases. A higher level of cytokines and a general inflammatory state has also been associated

Chemical composition, bactericidal kinetics, mechanism of action, and anti-inflammatory activity of Isodon melissoides (Benth.) H. Hara essential oil.

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Present study was aimed to investigate the antibacterial activity, bactericidal mechanism of action, killing kinetics and anti-inflammatory activity of Isodon melissoides (Benth.) H. Hara essential oil. The gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass

Nonsteroidal Anti-inflammatory-Organometallic Anticancer Compounds.

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Compounds that combine metal-based drugs with covalently linked targeted organic agents have been shown, in some instances, to exhibit superior anticancer properties compared to the individual counterparts. Within this framework, we prepared a series of organometallic ruthenium(II)- and

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