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Desmoteplase for late treatment of stroke: still in the dark.

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Optimal dark hole generation via two deformable mirrors with stroke minimization.

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The past decade has seen a significant growth in research targeted at space-based observatories for imaging exosolar planets. The challenge is in designing an imaging system for high contrast. Even with a perfect coronagraph that modifies the point spread function to achieve high contrast, wavefront

Delirium in patients with stroke: the dark side of the moon?.

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Acute Esophageal Necrosis: A View in the Dark.

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Acute esophageal necrosis (AEN), also known as Gurvits syndrome, black esophagus, or acute necrotizing esophagitis, is a rare clinical entity and an unusual reason for upper gastrointestinal bleeding. It is typically described in critically ill patients with multiple medical conditions, arising from

The role of the light-dark cycle and melatonin in stroke outcome.

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Recent work in experimental animals led us to formulate the hypothesis that the outcome of stroke is worse if it occurs during the day than during the night. This article describes the evidence in support of our proposal and explains that, although testing our concept in experimental animals is

Worsening risk factors and more strokes: the dark side of economic growth?

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Sarcoid vasculitis presenting with stroke: 3D T1 dark blood vessel wall imaging.

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Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex.

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Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABARs) sensing ambient levels of GABA can profoundly alter the membrane input resistance to affect cellular excitability. Therefore, regulation of tonic inhibition is an attractive mechanism to control the levels of cortical firing. In

Bright and dark vessels on stroke imaging: different sides of the same coin?

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OBJECTIVE Prominent hypointense cerebral vessels on susceptibility-weighted imaging (SWI) and the hyperintense vessel sign (HVS) on fluid-attenuated inversion recovery (FLAIR) imaging are considered as markers of compromised tissue perfusion in cerebral ischemia. In this study, we aimed to identify

The Dark Side of the Force - Constraints and Complications of Cell Therapies for Stroke.

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Cell therapies are increasingly recognized as a promising option to augment the limited therapeutic arsenal available to fight ischemic stroke. During the last two decades, cumulating preclinical evidence has indicated a substantial efficacy for most cell treatment paradigms and first clinical

Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke.

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In the primary visual cortex (V1), monocular deprivation (MD) induces a shift in the ocular dominance (OD) of binocular neurons towards the open eye (Wiesel and Hubel, 1963; Gordon and Stryker, 1996). In V1 of C57Bl/6J mice, this OD-plasticity is maximal in juveniles, declines in adults and is

Imbalance in the force: the dark side of the microbiota on stroke risk and progression.

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The composition of the gut microbiota depends on many factors, including our lifestyle, diet, metabolism, antibiotic use and hygiene. The contribution of these factors in shaping the gut microbiota and the subsequent effects on the prevention and development of stroke has been under intense

Clinical application of C-reactive protein in stroke prevention: bright and dark sides of the moon.

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In different study populations, several studies have shown that modest C-reactive protein elevation, in the range of apparently healthy individuals, is a strong predictor of future vascular events. Willcox and colleagues summarize the epidemiological and clinical observations that have led to the

The no-reflow phenomenon and dense fibrillary gliosis, cause of dark T2-weighted MR signal in stroke.

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Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

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Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the haemodynamic environment. Rapid haemodynamcis and disturbed blood flow, which occur in vessels with growing thrombi

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