dopamine/vermoeidheid

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Central fatigue induced by losartan involves brain serotonin and dopamine content.

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OBJECTIVE To investigate the influence of angiotensin II (Ang II) AT1 receptors blockade on central fatigue induced by brain content of serotonin (5-HT) and dopamine (DA) during exercise. METHODS Losartan (Los) was intracerebroventricularly injected in rats before running until fatigue (n = 6 per

Effect of dopamine agonists on fatigue and somnolence in Parkinson's disease.

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Dopamine agonists are becoming increasingly important in the treatment of early and advanced symptoms of Parkinson disease (PD). Although dopamine agonists are known to increase somnolence, their effect on fatigue and the relationship between fatigue and somnolence have not been investigated

Olprinone/dopamine combination for improving diaphragmatic fatigue in pentobarbital-anesthetized dogs.

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BACKGROUND Diaphragmatic fatigue might contribute to the development of respiratory failure. In particular, the spontaneous, natural rate of phrenic nerve discharge occurs mainly in low-frequency ranges making low-frequency fatigue clinically important in both humans and animals. Olprinone, a

Fatigue-related impairments in oculomotor control are prevented by norepinephrine-dopamine reuptake inhibition.

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Fatigue-induced reductions in saccade velocity have been reported following acute, prolonged exercise. Interestingly, the detrimental impact of fatigue on oculomotor control can be prevented by a moderate dose of caffeine. This effect may be related to central catecholamine upregulation via

Effects of noradrenaline and dopamine on supraspinal fatigue in well-trained men.

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OBJECTIVE Prolonged exhaustive exercise induces a failure of the nervous system to activate the involved muscles maximally (i.e., central fatigue). Part of central fatigue may reflect insufficient output from the motor cortex (i.e., supraspinal fatigue), but the cause is unresolved. To investigate

Treatment and prevention of diaphragm fatigue using low-dose dopamine.

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There is increasing evidence that diaphragm fatigue is a major cause of failure in weaning patients from mechanical ventilation. Patients in intensive care units are often administered dopamine to improve renal blood flow without regard to its effect on diaphragm blood flow. The aim of this study

Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making.

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During decisions, animals balance goal achievement and effort management. Despite physical exercise and fatigue significantly affecting the levels of effort that an animal exerts to obtain a reward, their role in effort-based choice and the underlying neurochemistry are incompletely known. In

Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function.

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In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of

The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders.

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Fatigue is one of the most pervasive symptoms of multiple sclerosis (MS), and has engendered hundreds of investigations on the topic. While there is a growing literature using various methods to study fatigue, a unified theory of fatigue in MS is yet to emerge. In the current review, we synthesize

Neuroplasticity of dopamine circuits after exercise: implications for central fatigue.

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Habitual exercise increases plasticity in a variety of neurotransmitter systems. The current review focuses on the effects of habitual physical activity on monoamine dopamine (DA) neurotransmission and the potential implication of these changes to exercise-induced fatigue. Although it is clear that

Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.

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Chronic exposure to interferon (IFN)-alpha, an innate immune cytokine, produces high rates of behavioral disturbances, including depression and fatigue. These effects may be mediated by the actions of IFN-alpha on dopamine (DA) metabolism in the basal ganglia. Diminished conversion of phenylalanine

Effects of Dopamine and Norepinephrine on Exercise-induced Oculomotor Fatigue.

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Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the upregulation of central

Dopamine-Mediated Yawning-Fatigue Syndrome With Specific Recurrent Initiation and Responsiveness to Opioids.

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Does fatigue in Parkinson's disease correlate with autonomic nervous system dysfunction?

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BACKGROUND Despite its negative impact on quality of life, fatigue in Parkinson's disease (PD) remains an under-recognized issue and the underlying pathology is undetermined. OBJECTIVE To contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD

Subjective fatigue and stress hormone levels in urine according to duration of shiftwork.

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To determine the associations between urinary catecholamines and cortisol and subjective complaints of fatigue in shiftworkers, we conducted a field survey of 113 male shiftworkers at a manufacturing company in South Korea from late October to late November in 1999. The shiftwork system in the

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