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Irinotecan-Associated Dysarthria in Patients with Pancreatic Cancer: A Single Site Experience

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BACKGROUND Irinotecan, a topoisomerase I inhibitor, is a cytotoxic chemotherapeutic agent used to treat multiple malignancies, including those of colorectal, pancreatic, cervical, esophageal, gastric, and lung origin. Dysarthria, a state of difficult or unclear articulation of speech, has been

Dysarthria in children with cerebellar or brainstem tumors.

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Speech features were perceptually analyzed in two groups of children. The first group (n = 6) had undergone cerebellar tumor resection, and the second group (n = 6) included children with brainstem tumors. Children belonging to the first group became dysarthric after a postoperative mute phase. Slow

Incidence of mutism, dysarthria and dysphagia associated with childhood posterior fossa tumour.

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OBJECTIVE Dysarthria and dysphagia are known complications following posterior fossa tumour (PFT) surgery. Outcome studies for these disorders, however, have focused on a select sub-group of children with mutism. Little is known regarding the incidence or features of these impairments in a

Dysarthria and dysphagia as long-term sequelae in a child treated for posterior fossa tumour.

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The current case report provides a comprehensive description of the persistent dysarthria and dysphagia evident in a 7.5 year old child treated for recurrent posterior fossa tumour (PFT). AC was assessed on a comprehensive perceptual and instrumental test battery incorporating all components of the

Incidence of dysarthria in children with cerebellar tumors: a prospective study.

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The present study investigated dysarthric symptoms in children with cerebellar tumors. Ten children with cerebellar tumors and 10 orthopedic control children were tested prior and one week after surgery. Clinical dysarthric symptoms were quantified in spontaneous speech. Syllable durations were

Role of cerebellum in fine speech control in childhood: persistent dysarthria after surgical treatment for posterior fossa tumour.

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Dysarthria following surgical resection of childhood posterior fossa tumour (PFT) is most commonly documented in a select group of participants with mutism in the acute recovery phase, thus limiting knowledge of post-operative prognosis for this population of children as a whole. Here we report on

Tumour type and size are high risk factors for the syndrome of "cerebellar" mutism and subsequent dysarthria.

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OBJECTIVE "Cerebellar mutis" and subsequent dysarthria (MSD) is a documented complication of posterior fossa surgery in children. In this prospective study the following risk factors for MSD were assessed: type, size and site of the tumour; hydrocephalus at presentation and after surgery, cerebellar

Transient loss of speech followed by dysarthria after removal of posterior fossa tumour.

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The authors report three children who suffered transient loss of speech during six to eight weeks following removal of a large midline cerebellar tumour. None manifested speech difficulties immediately after surgery, but all developed mutism within 24 to 48 hours. The speech of all children slowly

Mutism, oropharyngeal apraxia and dysarthria after posterior fossa tumour excision.

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Mutism and oropharyngeal apraxia are unusual complications of surgery on the cerebellum. They usually occur in children undergoing surgery for midline cerebellar tumours. Adults are rarely affected. The pathophysiology of the syndrome, which is reversible, is uncertain with possible involvement of

[Dysphagia and dysarthria due to the long-term growth of a tongue base tumor].

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Comment to the paper: incidence of mutism, dysarthria, and dysphagia associated with childhood posterior fossa tumor.

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What is the Etiology of Dysarthria and Ataxia in a Woman With Cancer?

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Pontine neoplasm or myelinolysis despite normal sodium levels.

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An elderly woman was transferred for biopsy of a pontine lesion. Her condition, including gait disturbances, truncal ataxia, and dysarthria - presumed to be due to a history of severe alcohol abuse - deteriorated over the course of treatment for ambulatory-acquired pneumonia. No electrolyte

Inflammatory myofibroblastic tumor of the cerebellar hemisphere--case report.

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A 60-year-old man presented with a rare cerebellar inflammatory myofibroblastic tumor (IMT) manifesting as gait disturbance and dysarthria. Brain magnetic resonance imaging demonstrated an intra-axial round-shaped isointense mass homogeneously enhanced with gadolinium in the right cerebellar

Malignant solitary fibrous tumor of the tongue.

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Solitary fibrous tumor is a generally benign spindle-cell neoplasm that has been predominantly described in the visceral pleura and other serosal sites and is extremely rare in the head and neck area. We report the first known case of malignant solitary fibrous tumor of the tongue in a 57-year-old

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