Amoxicilline-clavulanic acid (50-90 mg/kg/day, twice daily) and Lactobacillus reuteri DSM 17938 (5 drops per day, same time with the first dose of antibiotics).
Study Group 1a will received L. reuteri for 10-14 days. Study Group 1b will received L. reuteri for 21 days.

Amoxicillin-clavulanic acid (50-90 mg / kg / day) and placebo ( 5 drops per day, same time with the antibiotics) Study Group 2a will received placebo for 10-14 days. Study Group 2b will received placebo for 21 days.

Amoxicilline-clavulanic acid (50-90 mg/kg/day, twice daily) and Lactobacillus reuteri DSM 17938 (2 x 5 drops per day) Study Group 3a will received L. reuteri for 10-14 days. Study Group 3b will received L. reuteri for 21 days.

Amoxicillin-clavulanic acid (50-90 mg / kg / day) and placebo ( 2 x 5 drops per day, same time with the antibiotics) Study Group 4a will received placebo for 10-14 days. Study Group 4b will received placebo for 21 days.

Antibiotic Associated Diarrhea

Comparison the effects of L. reuteri and placebo for prevention of antibiotic associated diarrhea and also plan to compare the duration of treatment for on efficacy.

Lactobacillus reuteri DSM 17938

Comparison the effects of L. reuteri and placebo for prevention of antibiotic associated diarrhea and also plan to compare the duration of treatment for on

Placebo

All study patients will received amoxicillin-clavulanic acid at the dose of 50-90 mg/kg/day.

Amoxicillin-Clavulanic Acid

Sisli Etfal Training and Research Hospital,

Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children

Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children: Prospective, Multi-center, Randomize, Parallel Group Placebo Controlled Clinical Trial

The frequency and consistency of the stools were recorded daily according to Bristol score; a score <5 is described as normalization of stool and score equal or above 5 defined as diarrhea. Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug, Graded According to NCI CTCAE Version 3.0

The frequency and consistency of the stools were recorded daily according to Bristol score; a score <5 is described as normalization of stool and score equal or above 5 defined as diarrhea.

Presence of dehydration, requiring medical care, requiring hospitalization, Vesikari scale score

The Gastrointestinal Symptoms Rating Score, is a disease-specific instrument of 15 items combined into five symptom clusters depicting Reflux, Abdominal pain, Indigestion, Diarrhoea and Constipation. The Gastrointestinal Symptom Rating Score has a seven-point graded Likert-type scale where 1 represents absence of troublesome symptoms and 7 represents very troublesome symptoms.

Ener Cagri DINLEYICI

Professor in Pediatrics

Eskisehir Osmangazi University

Hacettepe University

Acıbadem University School of Medicine

Umraniye Education and Research Hospital

Sisli Hamidiye Etfal Training and Research Hospital

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Ege University Medical School

Bezmialem University Medical School

Yuzuncu Yıl University

Fırat University Medical School

Goztepe Training and Research Hospital

Erzurum Regional Training & Research Hospital

Namik Kemal University

No intervention mothers will recieve standard maternal and child care education

Peer counseling intervention group will recieve nutrition education on initiation of breastfeeding within one hour of delivery, continuation of exclusive breastfeeding until six months, and timely introduction of safe, nutritionally adequate complementary feeding after six months.

Infant Malnutrition

Pregnant Women

Lactating Mother

Breastfeeding

Infant Nutrition

Stunting

Peer counseling on infant feeding

Mirpur

Peer Conselling Infant Feeding Education Program

Peer Counselling to Improve Feeding Practices and Reduce Malnutrition in Children 0-2 Years in Bangladesh

We expect children in the intervention group (mothers getting counselling on breastfeeding and complementary feeding) will attain a better linear growth compare to control group (not receiving counselling).

Secondary objectives
The percentage of women exclusively breastfeeding (breast milk and no other foods or milk based liquids) their infants at 3 and 6 months will be increased, in the peer counselling group, compared with mothers without the intervention.
The percentage of children consuming foods from >4 food groups at 9, 12, 15 and 18 months will be increased, in peer counselling group, compared with mothers without the intervention.

dysentery/carbohydrate

Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children

Peer Conselling Infant Feeding Education Program

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