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Acute-onset epilepsy triggered by fever mimicking FIRES (febrile infection-related epilepsy syndrome): the role of protocadherin 19 (PCDH19) gene mutation.

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To report differences and similarities between febrile infection-related epilepsy syndrome (FIRES) and epilepsy in female patients with protocadherin 19 (PCDH19) mutation. These are two recently described epileptic conditions characterized by drug-resistant epilepsy and cognitive impairment. We

Novel mutations in SCN9A occurring with fever-associated seizures or epilepsy.

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This study aimed to identify disease-causing gene mutations in individuals belonging to the Southern Chinese Han population diagnosed with fever-associated seizures or epilepsy (FASE).Blood samples and clinical data were collected from 78 children with

PCDH19-related epilepsy and Dravet Syndrome: Face-off between two early-onset epilepsies with fever sensitivity.

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Aim of this study is to compare PCDH19-related epilepsy and Dravet Syndrome (DS) in order to find out differences between these two infantile epilepsies with fever sensitivity. We retrospectively reviewed the medical records of 15 patients with PCDH19-related epilepsy and 19 with DS. Comparisons

Epilepsy--another cause of intermittent fever with confusion.

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The problem of recurring episodes of fever and confusion in an 83 year old man was found to be due to epilepsy. He was treated with carbamazepine which abolished the attacks. Epilepsy-induced fever is a difficult diagnosis to make, and electroencephalogram can be invaluable in making the diagnosis.

Hyperthermia induces epileptiform discharges in cultured rat cortical neurons.

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Febrile seizures (FS), or fever-induced seizures, are the most common form of seizures during childhood. Although simple FS are usually considered benign, prolonged or recurrent FS are proposed to increase the risk for developing subsequent temporal lobe epilepsy (TLE) in adults. The pathophysiology

Neurobiological and physiological mechanisms of fever-related epileptiform syndromes.

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Febrile seizures (FS) are the most common type of convulsive events in children. FS have been extensively studied using animal models, where rat and mice pups are placed in a hyperthermic environment. Such work has largely focused on the consequences rather than on the mechanisms of experimental

Investigating the genetic basis of fever-associated syndromic epilepsies using copy number variation analysis.

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Fever-associated syndromic epilepsies ranging from febrile seizures plus (FS+) to Dravet syndrome have a significant genetic component. However, apart from SCN1A mutations in >80% of patients with Dravet syndrome, the genetic underpinnings of these epilepsies remain largely unknown. Therefore, we

[Recurrent episodes of fever of unknown origin as temporal lobe epilepsy].

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A 67-year-old woman was admitted to our department for the recurrent fever of unknown origin that occurred once approximately every 1 month for the last 3 years. No clinical and laboratory abnormality were found, except an interictal EEG showing fronto-temporal spike discharges. During

Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever".

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Of 290 children with an initial febrile convulsion, 216 met Livingston's criteria for a "simple" febrile convulsion and 74 for "epilepsy triggered by fever." Daily phenobarbital produced a significant decrease in febrile seizure recurrences in both groups, as compared to children who received

Timing and predictors of fever and infection after craniotomy for epilepsy in children.

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BACKGROUND Fevers and leukocytosis after pediatric craniotomy trigger diagnostic evaluation and antimicrobial therapy for possible brain infection. This study determined the incidence and predictors of infection in infants and children undergoing epilepsy neurosurgery. METHODS We reviewed the

Duration of recognized fever in febrile seizure predicts later development of epilepsy.

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BACKGROUND The current report examines the risk of and predictors for developing epilepsy in children with febrile seizure (FS). The present study addresses two factors that were previously identified as predictors of recurrent FS in previous reports: maximum temperature and duration of fever prior

Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

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BACKGROUND Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes

Duplications of 17q12 can cause familial fever-related epilepsy syndromes.

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OBJECTIVE After we identified a 17q12 duplication cosegregating in a 4-generation family with genetic or generalized epilepsy with febrile seizures plus (GEFS+), we aimed to determine the frequency of 17q12 genomic rearrangements in GEFS+ and a wide spectrum of other epilepsy phenotypes. We

Fever, febrile seizures and epilepsy.

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Seizures induced by fever (febrile seizures) are the most common type of pathological brain activity in infants and children. These febrile seizures and their potential contribution to the mechanisms of limbic (temporal lobe) epilepsy have been a topic of major clinical and scientific interest. Key

The genetics and molecular biology of fever-associated seizures or epilepsy.

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Fever-associated seizures or epilepsy (FASE) is primarily characterised by the occurrence of a seizure or epilepsy usually accompanied by a fever. It is common in infants and children, and generally includes febrile seizures (FS), febrile seizures plus (FS+), Dravet syndrome (DS) and genetic

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