exanthema/dl proline

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Tooth eruption and bone resorption: experimental investigation of the ia (osteopetrotic) rat as a model for studying their relationships.

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The osteopetrotic (ia) rat was examined as an experimental model for studying the dependence of tooth eruption on bone resorption. In ia rats eruption of incisors and first molars was rare and eruption of second and third molars was reduced and delayed. Autoradiographic studies of 3H-proline

Morphological and labeling evidence supporting and extending a modern theory of tooth eruption.

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As the interest in biological mechanisms of tooth eruption has recently been revived by a new eruption theory, the present study was an attempt to contribute new data to this problem. Four male Macaca fascicularis monkeys, two infant (about 13 months old) and two juvenile (about 44 months old), were

Metabolic turnover of collagen in the mouse molar periodontal ligament during tooth eruption.

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Metabolic turnover of collagen in the developing molar periodontal ligament was studied in 10, 12 and 16 days old mice by autoradiography after the administration of [3H]proline. Grain counts, in number per unit area, were made over three different zones (apical, middle and cervical) of the sections

Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption.

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Movement of fibroblasts in the periodontal ligament of the lower incisor of the mouse was studied by pulse-labeling with tritiated thymidine and proline. 3H-Thymidine was administered to mark the nuclei of the cells in the proliferative compartment near the basal end of the tooth; 3H-proline gave

Biological and biochemical properties of human rasH genes mutated at codon 61.

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Using site-directed mutagenesis, we have introduced mutations encoding 17 different amino acids at codon 61 of the human rasH gene. Fifteen of these substitutions increased rasH transforming activity. The remaining two mutants, encoding proline and glutamic acid, displayed transforming activities

In vivo experimentation on rat incisor enamel organs through a surgical window.

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Experimental agents administered systemically are costly and often toxic to animals. An in vivo technique has been developed whereby a surgical window in the alveolar bone allows selected areas of the rat incisor enamel organ and underlying enamel to be exposed to various drugs, radiolabeled

Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.

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OBJECTIVE The periodontal ligament (PDL) is thought to be an important tissue in vertical movement during tooth eruption, but the precise molecular mechanism is not known. Thereto, comprehensive gene expression was analyzed in human PDL of mandibular third molars performing vertical movement and

Relationship of abnormalities in dental and skeletal development in the osteopetrotic (os) rabbit.

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Osteopetrosis is a metabolic bone disease characterized by reduced bone resorption of heterogenous cause. The rabbit mutation is lethal and exhibits ultrastructural aberrations in osteoclasts and osteoblasts together with hypocalcemia, hypophosphatemia and failure to be cured by bone marrow

Age-dependent changes of the periodontal ligament in rats.

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Even after the end of the natural tooth eruption, there is a continuous renewal of the periodontal collagenous fiber system, depending on functional demands. The aim of this study was to analyse the age-dependent changes and regional differences of the collagen renewal rate of the periodontal

Genetic diagnosis in a Chinese Hailey-Hailey disease pedigree with novel ATP2C1 gene mutation.

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Hailey-Hailey disease (HHD) is an autosomal dominant skin disorder characterized by recurrent eruption of vesicles and bullae at the sites of friction and in the intertriginous areas. Mutations in the ATP2C1 gene encoding the human secretory pathway calcium ATPase 1 (hSPCA1) have been identified as

The effect of epidermal growth factor on neonatal incisor differentiation in the mouse.

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The effect of epidermal growth factor (EGF) on cellular differentiation of the neonatal mouse mandibular incisor was examined autoradiographically using tritiated thymidine ([3H]TDR) and tritiated proline ([3H]PRO). On days 0 (day of birth), 1, and 2, EGF was administered (3 micrograms/g body wt) sc

Radioautographic studies on amelogenesis.

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Radioautography has been used to visualize various aspects of morphogenesis and differentiation in the continuously erupting rat incisor. Formation of the entire incisor involves continuous production of "tooth segments" at the growing end of the tooth, each of which undergoes a similar history of

Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab.

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Somatic mutations in the epidermal growth factor receptor (EGFR) intracellular signalling pathways predict non-response to cetuximab in the treatment of advanced colorectal cancer (aCRC). We hypothesised that common germline variants within these pathways may also play similar roles. We analysed 54

Composition and metabolism of the extracellular matrix in the periodontal ligament of impeded and unimpeded rat incisors.

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Potential differences were studied in the composition and metabolism of the connective tissue components (collagen, non-collagenous proteins and glycosaminoglycans) of the periodontal ligament (PDL) as a result of alterations in the rate of eruption. The amount of collagen, glycosaminoglycan (GAG)

Changes in the composition of free amino acids and sugars of leaf sheath and culm of wheat during uredospore and teleutospore formation of Puccinia graminis tritici.

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There were altogether fourteen amino acids in leaf sheath and culm of wheat infected with Puccinia graminis tritici, especially in and around uredial and telial pustules. Valine, tyrosine, and proline, due to their exclusive presence in uredial pustules on leaf sheath and culm of wheat, were

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