During Hospitalization:
Patients routinely have blood drawn at time of admission and every 12 hours following admission up until 2 weeks post-admission or until discharge. Remnants of the blood draw will be stored in the Vanderbilt Lab core and retrieved for further analysis by key research personnel. Patients will have an additional 5.2ml of blood drawn (2 blue-top tubes) per time point during their normal course of care for this study, for a total of 72.8 mL of blood drawn per week. In addition to the routine blood draws, a finger stick may also be obtained the same day. Approximately 3 drops of blood (100μL maximum) will be removed by the finger stick.
Follow-Up Visits During routine care visits, we would like to obtain blood via one finger stick. A maximum of one blood draw via finger stick would be collected per month by research personnel, for up to two years.

During Hospitalization:
Patients routinely have blood drawn pre-, intra- and post-operatively. Remnants of the blood draw will be stored in the Vanderbilt Lab core and retrieved for further analysis by key research personnel. Patients will have an additional 5.2ml of blood drawn (2 blue-top tubes) immediately prior to surgery, every 30 minutes intraoperatively, every 6 hours for 3 days post-operatively, and every 12 hours from 3 days post-operative until discharge. Total blood volume drawn within one week will not exceed 150mL (~3% total blood volume).
Follow-Up Visits During routine care visits, we would like to obtain blood via one finger stick. A maximum of one blood draw via finger stick would be collected per month, for up to two years.

Blood will be taken from healthy, non-pregnant adults who weigh at least 110 pounds by research staff trained in venipuncture at a one-time study visit.

Acute Phase Response

Blood will be drawn from participants by venipuncture or by fingerstick.

Blood draw (venipuncture or fingerstick)

Vanderbilt Univeristy Medical Center

Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

Disorders of the Acute Phase Response Accelerated by Plasmin Activation Following Trauma and Invasive Surgery: A Prospective Study

A change in Interleukin-6 (IL-6) lab value following traumatic injuries or traumatic elective surgeries will be used to determine change in systematic inflammation.

A change in the Thrombin-antithrombin (TAT) complex following traumatic injuries or traumatic elective surgeries will be used to determine change in coagulation.

A change in d-dimer lab value following traumatic injuries or traumatic elective surgeries will be used to determine change in fibrinolysis.

Jon Schoenecker

Associate Professor of Orthopaedic Surgery, Associate Professor of Pediatrics

Vanderbilt University Medical Center

30 patients will receive intravenous 3mg/kg lidocaine 2 % (diluted with normal saline to 40 ml) + 0.5 mg neostigmine for Bier block.

30 patients will receive intravenous 3mg/kg lidocaine 2 % (diluted with normal saline to 40 ml) + 8 mg dexamethasone for Bier block.

Adjuvants, Anesthesia

Patients will receive intravenous 3mg/kg lidocaine 2 % (diluted with normal saline to 40 ml) + 0.5 mg neostigmine for Bier block.

Neostigmine

Patients will receive intravenous 3mg/kg lidocaine 2 % (diluted with normal saline to 40 ml) + 8 mg dexamethasone for Bier block.

Dexamethasone

Assiut university hospital

Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia

Efficacy of Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia for Forearm Orthopedic Surgeries

perfalgan will be given when visual analogue score ≥ 4

Percentage of patients with any complications will be recorded

MOHAMED F. MOSTAFA

Lecturer of Anesthesia and Intensive Care

Assiut University

Knee arthroscopy without the use of a thigh tourniquet.

Knee arthroscopy with the use of a thigh tourniquet.

Venous Thrombosis

Knee arthroscopy with the use of a thigh tourniquet that is inflated to 100-150 mmHg above systolic blood pressure.

Thigh Tourniquet

Knee arthroscopy

Groene Hart Ziekenhuis

Tourniquet Study: A Clinical Trial Into the Effect of Tourniquet Use on the Coagulation System

Tourniquet Study: Is the High Thrombosis Risk After Knee Arthroscopy Caused by Limb-tourniquet Application? A Randomized Clinical Trial Into the Effect of Tourniquet Use on the Coagulation System

Change in White Blood Cell Count (WBCC) between timepoints

Change in Neutrophil Extracellular traps (NETs) between timepoints

Change in Von Willebrand Factor (vWF) between timepoints

Change in Thrombomodulin between timepoints

Change in Prothrombin fragments 1+2 (f 1+2) between timepoints

Change in Plasmin Activator Inhibitor 1 (PAI 1) between timepoints

Change in Tissue plasminogen activator (tPA) between timepoints

Change in Thrombin and Antithrombin complexes (TAT) between timepoints

Change in Plasmin and antiplasmin complexes (PAP) between timepoints

The total duration of tourniquet inflation in minutes

Visibility during surgery, measured on a Visual Analogue Scale scale (0-10)

exsanguination/hypoxie

Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia

Tourniquet Study: A Clinical Trial Into the Effect of Tourniquet Use on the Coagulation System

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