gout/diarree

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Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol.

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OBJECTIVE To compare the characteristics of female versus male gout patients and assess urate-lowering efficacy and safety of febuxostat or allopurinol treatment in women with gout. METHODS This was a retrospective analysis of 4,101 hyperuricemic (serum urate [sUA] level ≥8.0 mg/dl) gout subjects

Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout.

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OBJECTIVE To review the pharmacology, pharmacokinetics, clinical trial data, safety profile, precautions, and place in therapy of febuxostat, a novel nonpurine xanthine oxidase inhibitor in development for the treatment of hyperuricemia and gout. METHODS Available studies and abstracts were

Febuxostat for prevention of gout attacks.

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(1) Febuxostat is a selective inhibitor of xanthine oxidase. Its use in the management of hyperuricemia and gout is being studied. (2) In a 52-week, phase III randomized clinical trial, febuxostat was superior to allopurinol for lowering uric acid levels. Its efficacy in preventing gout attacks was

2020 Recommendations From the French Society of Rheumatology for the Management of Gout: Management of Acute Flares

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Objective: To develop French Society of Rheumatology-endorsed recommendations for the management of gout flares. Methods: These evidence-based recommendations were developed by 9 rheumatologists (academic or community-based), 3

Vomiting, diarrhea, and sudden death with recent southeast asian travel : Fatal colchicine toxicity.

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A 41-year-old male was referred for autopsy from a hospital with a diagnosis of sepsis of uncertain etiology. As he had recently been attached to a military base in Southeast Asia, and had only just returned home, there was considerable concern that an unknown infectious agent may have been

[Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].

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OBJECTIVE To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR). METHODS The trial included 26 patients with gout (criteria of the American collage of rheumatologists) and IR (index HOMA). The inclusion criteria were the following: absence of antigout therapy,

Does colchicine work? The results of the first controlled study in acute gout.

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We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two-thirds of colchicine-treated patients improved after 48 hours, but only one-third of the patients receiving placebo demonstrated

High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study.

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OBJECTIVE Despite widespread use of colchicine, the evidence basis for oral colchicine therapy and dosing in acute gout remains limited. The aim of this trial was to compare low-dose colchicine (abbreviated at 1 hour) and high-dose colchicine (prolonged over 6 hours) with placebo in gout flare,

Chuanhu anti-gout mixture versus colchicine for acute gouty arthritis: a randomized, double-blind, double-dummy, non-inferiority trial.

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BACKGROUND The Chuanhu anti-gout mixture has been used for many years in the treatment of gout in Chinese Traditional Medicine, and current methods for treatments for acute gouty arthritis have been either less effective or have had serious side effects. METHODS In this 12-week, double-blind,

Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial.

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OBJECTIVE To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function. METHODS Subjects (n = 1,072) with hyperuricemia (serum urate level > or = 8.0 mg/dl) and gout

Colchicine for acute gout.

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BACKGROUND Gout is one of the most common rheumatic diseases worldwide. Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events. OBJECTIVE To evaluate the efficacy and safety of colchicine for relief of the signs and symptoms

Pharmacokinetic and clinical studies of carprofen in gout.

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Carprofen, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. After a single dose of 100 mg, plasma caprofen peaked in 1 to 2 hours, and t 1/2 was estimated to be 4.4 +/- 1.4 hours, based on a monoexponential fit of the data. Cumulative urinary excretion of total

An Ethnobotanical Study of Traditional Knowledge and Uses of Medicinal Wild Plants among the Marakwet Community in Kenya.

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Traditional plant knowledge and uses of medicinal wild plants were investigated among the Marakwet community in Kenya. Data were collected through interviews with seven traditional healers and 157 questionnaires for local community members. Traditional names of the plants by traditional healers and

The impact of perceived adverse effects on medication changes in heart failure patients.

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BACKGROUND Given the importance of patient safety and well-being, we quantified the likelihood and type of medication changes observed after 5 possible adverse effects (AE) perceived by heart failure (HF) patients. RESULTS We conducted a retrospective cohort study using 18 months follow-up data from

Colchicine poisoning complicated by medulla oblongata myelinolysis: a case report

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Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an

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