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Bladzijde 1 van 301 resultaten
Involvement of brain endogenous histamine in the degeneration of dopaminergic neurons in 6-hydroxydopamine-lesioned rats.
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Previous studies have suggested that brain histamine is involved in the pathogenesis of Parkinson's disease (PD), but the role of endogenous histamine in the degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc) remains unclear. We aimed to investigate this issue by
Cerebellar histamine-H1 receptor distribution: an autoradiographic study of Purkinje cell degeneration, staggerer, weaver and reeler mutant mouse strains.
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The distribution of 3H-mepyramine binding sites in cerebellae of normal mice and Purkinje cell degeneration, staggerer, weaver and reeler mutant mice was studied by light microscopic autoradiography. The binding of 3H-mepyramine to 20 micron coronal sections through the cerebellum and medulla had
Effect of Wallerian degeneration on histamine concentration of the peripheral nerve.
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One sciatic nerve of a White Leghorn hen was severed and the distal portion was allowed to undergo Wallerian degeneration. The change in histamine and DNA concentration and mast cell number was measured at different times following nerve sectioning in the proximal regenerating, distal degenerating,
Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration.
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OBJECTIVE
The present treatment for choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is not sufficient. Hence, we examined the therapeutic efficacy of reducing histamine H4 receptor expression on CNV in mice.
METHODS
H4 receptor expression was examined in
Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.
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Spasmolytic polypeptide (SP/TFF2)-expressing metaplasia (SPEM) is induced by oxyntic atrophy and is known as a precancerous or paracancerous lesion. We seek to determine whether the gastrin receptor or H(2) histamine receptor influence the development of SPEM. DMP-777 was administered to gastrin
Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy.
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We investigated histamine concentration in post-mortem brain samples of patients with Parkinson's disease (PD, n = 24), multiple system atrophy (MSA, n = 8) and age-matched controls (n = 27). Histamine concentrations were significantly increased in the putamen (to 159% of the control mean),
Blocking of histamine H2 receptors enhances parietal cell degeneration in the mouse stomach.
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The effects of the histamine H2 receptor antagonist, ranitidine, on parietal cell lineage was studied in the mouse stomach by using light and electron microscopy techniques. Mice were continuously infused for 15, 30, and 42 hr with ranitidine. Semithin sections examined under the light microscope
A FAILURE TO INDUCE GASTRIC ATROPHY IN DOGS BY ADMINISTRATION OF HISTAMINE-STIMULATED GASTRIC JUICE.
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Global Deterioration Scale-related brain hemodynamics and histamine levels in Alzheimer's disease and vascular dementia.
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Morphology and immuno-distribution of the histamine H4 receptor and histamine--releasing factor in choroid plexus of patients with paraneoplastic cerebellar degeneration.
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[Comparative actions of histamine and a "synthetic anthistaminic" (N-dimethylamino-2-propyl-1-thiodiphenylamine) on the atrophy of the genital tract of female virgin mice after remote application of Norwegian tar].
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[The content of histamine in the blood of patients with hepatolenticular degeneration (before and after therapy with thio compounds)].
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Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells.
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Multiple sclerosis (MS) is an inflammatory disease that is characterized by immune-mediated demyelination and degeneration of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the preferential experimental rodent model for MS. Previous study demonstrated histamine
Effects of cutaneous histamine application in patients with sympathetic reflex dystrophy.
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Thirty-six patients suffering from acute reflex sympathetic dystrophy (RSD) were examined in order to evaluate nociceptive C-fibers. Axon reflex vasodilatation was induced by iontophoresis of histamine and recorded (laser Doppler flux). The strength of concomitant sensation was rated on a visual
Modulation of dopamine D 1 receptors via histamine H 3 receptors is a novel therapeutic target for Huntington's disease
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Early Huntington's disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1R and
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