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Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
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BACKGROUND OF THE INVENTION
SAH hydrolase has been an attractive target for antiviral drug design based on the observation that many viruses require 5'-capped, methylated structures on their mRNA for efficient translation of viral proteins. Yuan et al., Exp. Opin. Ther. Patents, 9: 1197-1206 (1999);
Reversible inhibitors of SAH hydrolase and uses thereof
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BACKGROUND OF THE INVENTION
SAH hydrolase has been an attractive target for antiviral drug design based on the observation that many viruses require 5'-capped, methylated structures on their mRNA for efficient translation of viral proteins. Yuan et al., Exp. Opin. Ther. Patents, 9: 1197 1206 (1999);
Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
Alleen geregistreerde gebruikers kunnen artikelen vertalen
Log in Schrijf in
BACKGROUND OF THE INVENTION
SAH hydrolase has been an attractive target for antiviral drug design based on the observation that many viruses require 5'-capped, methylated structures on their mRNA for efficient translation of viral proteins. Yuan et al., Exp. Opin. Ther. Patents, 9: 1197-1206 (1999);
Substituted piperidines as soluble epdxide hydrolase inhibitors
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BACKGROUND OF THE INVENTION
Pain is generally divided into nociceptive and neuropathic pain. Nociceptive pain stems from neural pathways in response to tissue damaging or potentially tissue damaging signals, and includes inflammatory pain. Neuropathic pain tends to relate to dysfunctions within the
Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Phase application under 35 U.S.C. .sctn.371 of International Application No. PCT/EP2014/076263 filed Dec. 2, 2014, which claims priority benefit to EP Application No. 13306663.9 filed Dec. 4, 2013, the disclosures of each of
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