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8 resultaten
Glycoside-hydrolase enzyme inhibitors
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BACKGROUND OF THE INVENTION
Carbohydrates are eaten either as simple sugars or as more complex molecules called polysaccharides, which are built up from simple sugar units and of which the starch of potatoes, bread, etc., is a well-known example. The body absorbs carbohydrates from the small
Glycoside-hydrolase enzyme inhibitors
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BACKGROUND OF THE INVENTION
Carbohydrates are eaten either as simple sugars or as more complex molecules called polysaccharides, which are built up from simple sugar units and of which the starch of potatoes, bread, etc., is a well-known example. The body absorbs carbohydrates from the small
N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
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BACKGROUND
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile.
BRIEF SUMMARY OF THE INVENTION
This
Anti-cancer serine hydrolase inhibitory carbamates
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BACKGROUND
A major challenge facing biological researchers in the 21.sup.st century is the functional characterization of the large number of unannotated gene products identified by genome sequencing efforts. Many proteins partly or completely uncharacterized with respect to their biochemical
Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity
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OBJECTS OF THE INVENTION
It is an object of the invention to control weight in humans by ingesting acarbose with meals with food containing carbohydrates.
This and other objects and advantages will become obvious from the following detailed description.
THE INVENTION
The invention is directed to a
Polyhydroxycyclopentane derivatives, their preparation and their therapeutic use
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BACKGROUND TO THE INVENTION
The present invention provides two novel polyhydroxycyclopentane derivatives which have certain valuable biological activities and provides methods of preparing these compounds as well as methods and compositions using them for therapeutic and prophylactic purposes.
The
Combination of biologically active substances for treatment of hyperglycaemic disorders
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RELATED APPLICATIONS
This application is the National Stage of International Patent Application No. PCT/EP2015/060743, filed May 15, 2015, which is hereby incorporated by reference in its entirety, and which claims priority to European Patent Application No. 14168754.1, filed May 16, 2014.
The
Amylase inhibitor
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BACKGROUND OF THE INVENTION
It is known that in animals and man, after the intake of starchy foodstuffs and beverages, hyperglycaemias arise which are caused by a rapid splitting of the starch by amylases of the digestive tract according to the following equation:
These hyperglycaemias are
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