hydroxylamine/hypoxie

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Neurochemical effects of ingested hydroxylamine.

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Hydroxylamine chloride (0.3 g/l) in drinking water was given to 3-mo-old male Wistar rats for 1 to 63 days. The treatment caused splenomegalia while no effect was noted on the weight gain. Cerebral RNA content was also unaffected whereas slight decrease in the cerebral homogenate and isolated glial

Glutathione reductase activity and chilling tolerance are induced by a hydroxylamine derivative BRX-156 in maize and soybean.

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The possible contribution of antioxidants in the improvement of stress tolerance induced by the hydroxylamine derivative BRX-156 was studied in two thermophilic crops, soybean (Glycine max (L.) Merr.) and maize (Zea mays L.) both during germination and at the seedling stage. The most effective

Hydroxylamine reduction to ammonium by plant and cyanobacterial hemoglobins.

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Plants often face hypoxic stress as a result of flooding and waterlogged soils. During these periods, they must continue ATP production and nitrogen metabolism if they are to survive. The normal pathway of reductive nitrogen assimilation in non-legumes, nitrate, and nitrite reductase can be

Biochemical changes in the intestine associated with anoxia and reoxygenation: in vivo and in vitro studies.

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In ischemia/reperfusion injury, it is hypothesized that superoxide is responsible for the component of injury due to reperfusion. The superoxide is hypothesized to result from the aerobic oxidation of purines produced by the ischemia-mediated breakdown of high-energy phosphates. This oxidation is

Protective action of endogenously generated H₂S on hypoxia-induced respiratory suppression and its relation to antioxidation and down-regulation of c-fos mRNA in medullary slices of neonatal rats.

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We previously reported that exogenous H(2)S played roles in protection of respiratory centers against hypoxic injury in medullary slices of neonatal rats. The protective action of endogenous H(2)S and its relation to antioxidation and down-regulation of c-fos mRNA were investigated in the present

Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.

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BACKGROUND PR-104 is rapidly hydrolyzed to PR-104A in vivo, which is activated by reduction to the corresponding 5-hydroxylamine (PR-104H) and amine (PR-104M) to produce DNA interstrand cross-links. PR-104 activation can occur via hypoxia-dependent reductases and also independently of hypoxia by

Mechanisms and specific directionality of autotrophic nitrous oxide and nitric oxide generation during transient anoxia.

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The overall goal of this study was to determine the molecular and metabolic responses of chemostat cultures of model nitrifying bacteria to imposition of and recovery from transient anoxic conditions. Based on the study, a specific directionality in nitrous oxide (N(2)O) and nitric oxide (NO)

Hypotensive effects of hydroxylamine in intact anesthetized dogs and cats.

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When given IV in bolus doses to intact anesthetized dogs or cats, hydroxylamine hydrochloride produced transient but precipitous falls in the mean arterial blood pressure in a dose-related manner, as well as a significant methemoglobinemia. The half-time for recovery of the mean arterial pressure

Antihypoxic effect of the hydroxylamine derivative HB-7.

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The antihypoxic effect of the newly-synthesized hydroxylamine barbiturate HB-7, compared with the effects of phenobarbital and pentobarbital, was studied in experiments on albino mice, using the following models of hypoxia: hypobaric, anoxic, asphyctic and haemic. A dose-effect dependence was

Hypoxia-stimulated reduction of doxyl stearic acids in human red blood cells. Role of hemoglobin.

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Nitroxide free radicals are under active investigation for their potential use as metabolically responsive contrast agents in electron paramagnetic resonance and nuclear magnetic resonance imaging. The metabolism in human red blood cells of lipid-soluble nitroxides, doxyl stearic acids (DSA), has

[Antiradical and antioxidant effect of arginine and its action on lipid peroxidation in hypoxia].

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Arginine (0.5 and 1 mu mol) decreased by 14-17% rates of superoxide anion formation in two systems: HADH-phenazine methosulfate and hydroxylamine autooxidation with nitrotetrazolium blue. These concentrations of arginine decreased by 40-50% formation of diene conjugates and Schiff bases in plasma

Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide.

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Our objective was to determine whether hydroxylamine is a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Vasorelaxation by hydroxylamine is known to be mediated by nitric oxide. The vasorelaxant properties of hydroxylamine were examined using rat aortic rings and an

Hypoxia-selective antitumor agents. 11. Chlorambucil N-oxide: a reappraisal of its synthesis, stability, and selective toxicity for hypoxic cells.

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The potential hypoxia-selective cytotoxin 4-[4'-[N,N-bis(2"-chloroethyl)amino]phenyl]butanoic acid N-oxide (chlorambucil N-oxide, 4) was synthesized and characterized as its hydrochloride salt. This compound was shown to be unstable, decomposing in some organic solvents to the hydroxylamine

Nitroaryl compounds as potential fluorescent probes for hypoxia. II. Identification and properties of reductive metabolites.

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Nitroakridin 3582 (NA) and a nitronaphthalimide (DM113), which fluoresce only upon reduction, have been studied by HPLC. V79-379A cells incubated with NA under 20% or 2% O2 and N2 gave increasing amounts of the fluorescent amine with an hypoxic:oxic differential of 160. Measurement of the uptake of

Determination of hypoxia-inducible factor-1 by using a ratiometric colorimetric test based on click-mediated growth of gold nanoparticles.

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The authors describe a significantly improved colorimetric nanoprobe for the determination of transcription factors (TFs). It is making use of click-mediated growth of gold nanoparticles (AuNPs) to amplify the signal-to-noise ratio. Hypoxia-inducible factor-1 (HIF-1) is an important TF that acts as

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