This group of patients will receive single high dose of vitamin D (Cholecalciferol) dissolved in 45 ml of fresh milk (Nestle)

This group of patients will receive placebo - 45 ml of fresh milk (Nestle) so that the amount, color, smell, taste etc will be the same as that of experimental drug)

Vitamin D Deficiency

Critical Illness

400000 international Units of cholecalciferol will be dissolved in 45 ml of fresh milk (Nestle) and it will be given to interventional group patients through enteral route within 24 hours of ICU admission as a single dose.

Cholecalciferol

45 ml of Nestle milk will given to patients assigned as placebo

Milk (Nestle)

King Abdullah Medical City, Holy Capital

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency in Intensive Care Unit- A Randomized Controlled Trial.

as evidenced by microbiological culture and sensitivity reports from samples taken from patients blood, sputum,urine and body fluids.

as evidenced by invasive blood pressure monitoring during ICU stay.

How long the patient will stay in Hospital

It will be assessed by rising serum creatinine level and decreasing urine out put per hour.

as evidenced by neurological deficit and CT sacn/MRI findings

It will be assessed by decreasing hemoglobin levels and endoscopic findings.

including, acute kidney injury, Myocardial Infarction, Cerebrovascular accidents, upper or lower gastro intestinal bleed)

Asiah Rugaan

Consultant and Head of Department - Intensive Care Unit

King Abdullah Medical City

Volunteers assigned to this arm will receive a single dose of oral cholecalciferol 300 000 IU, in the form of 3 ml D-cura drink 100 000 IU/ml

Volunteers assigned to this arm will receive a single dose of oral cholecalciferol 75000 IU, in the form of 3 ml D-cura drink 25 000 IU/ml

Atherosclerosis

Oxidative Stress

Leukocyte Activation Disorder

Single dose D-cura cholecalciferol drink 100 000 IU/ml, in total 300 000 IU (=3ml)

Single dose D-cura cholecalciferol drink 250 000 IU/ml, in total 75 000 IU (=3ml)

Sint Franciscus Gasthuis

Effects Vitamin D Suppletion on Postprandial Leukocyte Activation

Effects of High and Low Dose Vitamin D Suppletion on Postprandial Leukocyte Activation, Oxidative Stress and Vascular Function in Healthy Overweight and Obese Females

the differential effect of 75 000 IU low dose vs. 300 000 IU high dose vitamin D on postprandial leukocyte activation markers cluster of differentiation antigen 11b

the differential effect of 75 000 IU low dose vs. 300 000 IU high dose vitamin D on oxidative stress

the differential effect of 75 000 IU low dose vs. 300 000 IU high dose vitamin D on vascular function (Pulse Wave Velocity and Augmentation Index)

M.A. de Vries

Dietary supplement of vitamin D3 and calcium

Dietary supplement of vitamin D3 and calcium
Vitamin D3 and Calcium: 1500 mg of calcium citrate plus 1000 IU of vitamin D3 and 1000 IU of vitamin D3 bariatric supplements per day

Vitamin D3 and Calcium

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

BMI, kg/m^2

Body weight, lb

Excess body weight, lb

Surgery type

Serum 25(OH)D ng/ml levels at baseline and 12 weeks following bariatric surgery

Vitamin D Concentrations, Pre Operative and Post Bariatric Surgery Following 12 Weeks of Vitamin D Supplementation

We anticipate that vitamin D supplementation of Roux-en Y bariatric surgery patients will be less effective in improving or maintaining vitamin D status.

Sleeve Gastrectomy

Roux-Y Gastric Bypass

Serum 25-hydroxyvitamin D Levels at Baseline and 12 Weeks of Daily Vit D Supplementation Post Roux-en Y OR Sleeve Gastrectomy

Overall Study

Sherman Vadim

Obesity

1500 mg of calcium citrate plus 1000 IU of vitamin D3 and 1000 IU of vitamin D3 bariatric supplements per day

The Methodist Hospital

Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients

Preoperative Vitamin D Status and Efficacy of Therapeutic Vitamin D Supplementation Postoperatively in Bariatric Surgery Patients

Vadim Sherman, MD

Sponsor-Investigator/Principal Investigator

Texas Woman's University

The Methodist Hospital System

Subjects receive PTHrP(1-36) starting with doses of 2 picomoles (pmols)/kg/hr for one week. Subsequent dosing groups are determined by the response to PTHrP doses.

Subjects receive PTH(1-34) starting with doses of 2 picomoles (pmols)/kg/hr for one week. Subsequent dosing groups are determined by the response to PTH doses.

Osteoporosis

Hypercalcemia of Malignancy

Hyperparathyroidism

Bone Diseases, Endocrine

PTHrP (1-36) intravenously at 2 picomoles (pmols)/kg/hr for one week; doses will be increased by 2 picomoles (pmols)/kg/hr in subsequent subjects.

Parathyroid Hormone-related Protein (1-36)

PTH (1-34) intravenously at 2 picomoles (pmols)/kg/hr for one week; doses will be increased by 2 picomoles (pmols)/kg/hr in subsequent subjects.

parathyroid hormone (1-34)

This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers. The investigators plan to infuse low doses of intravenous PTHrP or PTH to determine if it leads to a sustained and progressive suppression of bone formation as occurs in humoral hypercalcemia of malignancy (HHM) or an increase in bone formation as occurs in hyperparathyroidism (HPT). Additionally, the investigators will assess the direct influence of PTHrP and PTH on vitamin D metabolism, markers of bone turnover, and fractional excretion of calcium.

PTH (1-34) and PTHrP (1-36)

University of Pittsburgh Medical Center

One Week Comparison Study of PTH and PTHrP Infusions

Comparison of Skeletal and Mineral Metabolism Responses in Healthy African-Americans and Caucasians Using a Continuous Seven-Day Parathyroid Hormone (PTH) or Parathyroid Hormone-related Protein (PTHrP) Infusion

hypercalcemia/obesitas

Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.

Effects Vitamin D Suppletion on Postprandial Leukocyte Activation

Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients

One Week Comparison Study of PTH and PTHrP Infusions

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