hypercalcemia/obesitas

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Slight hypercalcemia is not associated with positive responses in the Comet Assay in male rat liver.

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Maintenance of physiological levels of intracellular and extracellular calcium is essential for life. Increased intracellular calcium levels are involved in cell death (apoptosis and necrosis) and are associated with positive responses in the Comet assay in vitro. In addition, high calcium and

Elevation of calcitonin immunoreactivity in the pituitary and thyroid glands of genetically obese rats (fa/fa).

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This paper contains the first demonstration of quantitative changes in the levels of calcitonin-like immunoreactivity in the pituitary. The concentration of calcitonin-like material in lean Zucker rats (?/+) was 0.42 +/- 0.09 ng/mg wet weight of pituitary. The pituitaries of obese rats (fa/fa)

Obesity attenuates serum 25-hydroxyvitamin D response to cholecalciferol therapy in critically ill patients.

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The presence of obesity may confound cholecalciferol dosing in vitamin D-deficient patients owing to potentially decreased bioavailability. The aim of this retrospective study was to evaluate cholecalciferol therapy in vitamin D-deficient, critically ill trauma patients with and

Nutrition support in the morbidly obese, critically ill patient.

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Nutrition support in the critically ill patient is challenging but is even more difficult in a morbidly obese patient. This case report chronicles the care of a 6-foot-tall, 256-kg male (body mass index 76.5 kg/m(2)) who spent over a month in the intensive care unit for respiratory failure, sepsis,

The role of vitamin D metabolites in hypercalcemia of Zucker fa/fa rats.

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In order to investigate mineral and vitamin D metabolism in obese rats with hyperinsulinemia, plasma calcium and vitamin D metabolites were measured in Zucker fa/fa rats. Body weight, plasma insulin, and calcium in fa/fa rats were significantly increased compared to their lean littermates (p less

Calcitonin mRNA activity in genetically obese rats.

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The etiology of the alterations in calcitonin (CT) secretion and plasma calcium of genetically obese (fa/fa) rats is unknown. In this study, we tested the postulate that there is an early occurrence of abnormalities in CT biosynthesis by thyroid glands of these rodents. Male genetically obese Zucker

Crinophagy in Thyroid Follicular and Parafollicular Cells of Male Obese Zucker Rat.

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Comparison between lean (Fa/?) and obese (fa/fa) young adult male Zucker rat thyroids reveals that obese rats display larger clusters of parafollicular cells than the lean ones with a lesser blood supply. Fa/? thyroid typically shows single or "twin" C cells in follicles; fa/fa parafollicular cells

Misleading acute hypercalcemia due to hyperlipidemia: a method-dependent error.

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OBJECTIVE To report a case of artifactual hypercalcemia in a patient with hyperlipidemia. METHODS We present clinical data and laboratory findings in a 33-year-old woman with generalized fatigue, a recent 5-kg weight loss, and a papular rash on the extremities as well as a history of diabetes and

Efficacy and safety of the bisphosphonate tiludronate for the treatment of tumor-associated hypercalcemia.

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Tiludronate is a new bisphosphonate whose efficacy has already been reported for the prevention of postmenopausal bone loss. We have evaluated its efficacy and tolerance by a dose-finding study in 19 hypercalcemic cancer patients after adequate intravenous (iv) rehydration. Treatment consisted of 3

Phosphate removal with several thrice-weekly dialysis methods in overweight hemodialysis patients.

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BACKGROUND Currently available phosphate binders are associated with either hypercalcemia or high costs, which limit their use in hemodialysis patients. Whether modifying dialysis prescription to intensify small-solute clearance also leads to better phosphate clearance is unknown. METHODS Randomized

Dose/response study of aminohydroxypropylidene bisphosphonate in tumor-associated hypercalcemia.

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Bisphosphonates (or diphosphonates) constitute a major advance in the treatment of tumor-associated hypercalcemia and also have the potential to prevent or reverse osteolysis in normocalcemic patients. Available information on adequate therapeutic doses and potential toxicity is, however, very

Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: a case-control study.

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OBJECTIVE Bisphosphonates (BPs) effectively treat metastatic bone disease, hypercalcemia, and osteoporosis. BP exposure, however, may be associated with osteonecrosis of the jaw (ONJ). The aim of the present study was to estimate the magnitude of the association between intravenous (IV) BP exposure

25-Hydroxyvitamin D response to graded vitamin D₃ supplementation among obese adults.

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BACKGROUND Guidelines have suggested that obese adults need 2 to 3 times more vitamin D than lean adults to treat vitamin D deficiency, but few studies have evaluated the vitamin D dose response in obese subjects. OBJECTIVE The purpose of this study was to characterize the pharmacokinetics of

Calcium metabolism in the morbidly obese.

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BACKGROUND Morbidly obese patients are known to have abnormal calcium metabolism compared with the non-obese, but the clinical significance of this is unknown. Since surgical treatment of obesity may itself cause hyperparathyroidism, it is important to understand the preoperative physiology of these

Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.

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Obese children are vulnerable to vitamin D deficiency and impaired cardiovascular health; vitamin D replenishment might improve their cardiovascular health.The aims were to determine, in vitamin D-deficient overweight and obese children, whether

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