Compounds of formula (I), ##STR00001## or pharmaceutically acceptable derivatives thereof, wherein R represents H, C.sub.1-6 alkyl, SO.sub.2R.sup.1, SO.sub.2NR.sup.1R.sup.2, or COR.sup.1; R.sup.1 and R.sup.2 independently represent C.sub.1-6 alkyl; and Ring A represents a phenyl ring or a pyridinyl ring; may be useful in the treatment of anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.

Pfizer Inc.

Triazolobenzodiazepines and their use as vasopressin antagonists

Compounds of formula (I), ##STR00001## or pharmaceutically acceptable derivatives thereof, wherein: Het represents 2-pyridinyl or 2-pyrimidinyl; R.sup.1 represents H, C.sub.1-3 alkyl or a nitrogen-containing heterocyclic ring having 5 or 6 ring atoms; R.sup.2 represents H, benzyl or C.sub.1-3 alkyl; and R.sup.3 represents H, methyl, methoxy or chloro; are useful for treating anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.

hypernatremia/oedeem

Triazolobenzodiazepines and their use as vasopressin antagonists

Triazole derivatives which inhibit vasopressin antagonistic activity

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