(30) patients will apply topical minoxidil (5%) once daily and topical cetirizine (1%) once daily on their scalp for 6 months.

(30) patients will apply topical minoxidil (5%) once daily and placebo once daily on their scalp for 6 months.

Androgenetic Alopecia

Females with androgenetic alopecia of age 20-50.

Topical cetirizine 1% spray that will be prepared at Faculty of Pharmacy, Cairo University and will be applied once daily.

Topical cetirizine

96% ethanol that will be applied once daily.

Placebo

Topical Minoxidil 5% that will be applied once daily.

Topical minoxidil

Al-Kasr Al-Ainy outpatient dermatology clinic

Topical Cetirizine in Androgenetic Alopecia in Females

The Role of Cetirizine in Androgenetic Alopecia in Females

Trichoscopic evaluation: of frontal, occipital and temporal areas regarding the change from baseline in number of terminal hairs, growing hair and vellus hair.

Trichoscopic evaluation: of frontal, occipital and temporal areas regarding the change from baseline in hair shaft thickness.

Trichoscopic evaluation: of frontal, occipital and temporal areas regarding the change from baseline in number of follicular openings.

Trichoscopic evaluation: of frontal, occipital and temporal areas regarding the change from baseline in number of hairs erupting from each follicle.

Patient self-assessment of hair growth will be determined by means of a set of predetermined 5 questions in Arabic, each of which asks the patient about a specific aspect of their hair compared with the start of the study.

Standardized photographs of the scalp will be taken.
An expert panel of 3 blinded dermatologists will evaluate hair growth or loss from baseline by comparing baseline with follow-up photographs of each subject by means of a 7-point scale to answer the following question: "How would you subjectively rate the patient's hair growth at this time point compared to baseline?". The scale ranges from-3 ( greatly decreased) to +3 (greatly increased). Assessments will be made at the 12th and 24th week by comparing the global photographs taken at baseline with those taken at each visit.
Investigator assessment: Same as the expert panel assessment.

Reports of adverse effects or local intolerance, if any, will be collected at every visit.

hypertrichosis/hoofdpijn

Topical Cetirizine in Androgenetic Alopecia in Females

Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia

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