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Toe-brachial Index and Coronary Calcification in Type 1 and 2 Diabetes

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Cardiovascular disease is the most common cause of death in diabetes. Actually, systematic screening of asymptomatic diabetic patients for silent myocardial ischemia is highly controversial, and is recommended for selected high-risk patients. Calcium artery calcification score predicts major

Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest

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Bed rest is a widely accepted experimental model used to study physiological adaptations to space flight, including bone and muscle mass loss, fluid shift, and cardiovascular deconditioning. Generally, participants are asked to spend a period in bed, with all activities of daily living being

Screening of Diastolic Dysfunction With Impedance Cardiography in Hypertensive Patients

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BACKGROUND. Impedance cardiography (IC) is a complementary diagnostic test used in the study of arterial hypertension (AHT) and in the optimization of antihypertensive therapy. It is easy-to-execute, non-operator-dependent and cost-effective. It analyses and registers hemodynamic changes through the

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension

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Introduction Resistant hypertension (RH) is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions, at their maximum recommended tolerated doses for at least six months; one preferably should be a diuretic.

Influence of Dexmedetomidine or Propofol on ICU Delirium

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Dexmedetomidine is a potent selective α-2-adrenergic receptor agonist frequently used for sedation in the ICU, also among critically ill patients. It promotes sedation, anxiolysis, and moderate analgesia with minimal respiratory depression. Sedation of ICU patients remains challenging for doctors

Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients

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Main objective / secondary: Primary objective : To determine the prevalence of a small fiber peripheral neuropathy in nondiabetic obese patients, by measuring skin conductance ion Chlorine (Sudoscan®) evaluating small fibers C autonomic Secondary objectives: - Evaluation of the prevalence of

Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction

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This is a single centre study, which will comprise of a cross-sectional analysis of the baseline data of a 3-arm 12 week Prospective, Randomised, Open label, Blinded End point (PROBE) trial of TDR and an exercise programme compared with standard care. Clinical follow-up will take place at 6-12

RIGENERA 2.0 Trial

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1. INTRODUCTION 1.1. BACKGROUND AND RATIONALE OF THE STUDY The long term prognosis of patients suffering from acute myocardial infarction (AMI) has progressively improved since the introduction of reperfusion therapies and in particular primary angioplasty [1]. In the setting of ST-elevation

Cilostazol and Its Effects on Resumption of Meiosis in the Human Ovary

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Combined oral contraceptive pills (COCs) are the most commonly used hormonal form of birth control in the United States with at least 87% of women of reproductive age reporting oral contraceptive use at some point in their lives (9). Despite their frequent use, the six and twelve month

Sexual Dysfunction in Type 2 Diabetic Women

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In an estimated temporal space of about 3 years, 306 women will be recruited consecutively. After collection of written informed consent, the following data will be collected: - History: type of diabetes, comorbidities, current medication, duration of diabetes and complications, voluptuary habits

Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury

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The early identification of individuals at high risk for development of CVD has been a challenging and highly relevant pursuit for clinicians and epidemiologists. The clinical significance of early identification of CAD becomes apparent because several of the cardiac risk factors are modifiable.

Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH)

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Inclusion Criteria - Calcium scan with Agatston score >20 - Age 35-84 years - Subjects must provide written informed consent after the scope and nature of the investigation has been explained to them - Subjects should be stable on their concomitant medications for at least 12 weeks prior to

Comparison of Cognitive Functions of Schizophrenic Patients Treated With Sertindole Versus Risperidone

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Introduction: In this proposal we intend to compare the effect of Sertindole to that of Risperidone on cognitive impairment in schizophrenia. Hypothesis: Sertindole will be as effective as Risperidone for treating cognitive impairment in schizophrenia and with fewer side effects. Study

The Effect of a Complementary Multi Disciplinary Program on Blood Pressure in Hypertensive Patients

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Intervention description Complementary Approaches to Lower Mean arterial pressure (CALM) utilizes a naturopathic dietary approach, education on cooking and food consumption choices, walking physical exercise, Qi Gong - a form of Chinese slow movement exercise combined with relaxation breathing and

Ziprasidone for Clozapine- or Olanzapine-Associated Diabetes Mellitus

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Specific Aims: This study is a six-week, open label trial of the novel antipsychotic agent, ziprasidone, added to a stable dose of clozapine or olanzapine in 40 diabetes mellitus patients, patients with an impaired fasting glucose or insulin resistance with schizophrenia or schizoaffective

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