Peripubertal girls with varying androgen concentrations will have careful phenotype/genotype assessment, primarily to assess the relationship between urinary exosomal DENND1A.V2 and serum free testosterone concentrations.

Optional sample banking for later genetic analysis: At the time of study, the investigators will request consent/assent to bank saliva samples for later genetic analysis (e.g., if additional highly-promising gene candidates for adolescent hyperandrogenemia/PCOS are identified). If subjects and parents do not provide assent/consent that would allow specimens to be banked for later genetic analysis, the samples and the means of linking specimens to data will be destroyed (once analysis for all participants is completed).

Polycystic Ovary Syndrome

Hyperandrogenism

Puberty

The investigators will perform careful phenotyping in addition to hormonal assessments and assessments of DENND1A

Phenotype/genotype assessment

Center for Research in Reproduction

Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia

Body mass index normalized for age and gender

Serum luteinizing hormone (LH) measured at same time as free testosterone and fasting insulin

Serum insulin measured at same time as free testosterone and morning LH

We do not have current plans to share IPD

infertility/dl proline

Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia

De meest complete database met geneeskrachtige kruiden, ondersteund door de wetenschap