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infertility/obesitas
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Methods and systems for assessing infertility and related pathologies
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BACKGROUND
According to the Centers for Disease Control and Prevention, 6.7 million women (around 10.9%) in the United States between the ages of 15 and 44 suffer from impaired fecundity, or the ability to become pregnant and carry a baby to term. See Chandra A, Copen C E, Stephen E H. Infertility
Obesity gene
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CROSS-REFERENCE TO RELATED APPLICATION
This application claims priority under 35 U.S.C. .sctn.120 to International Application serial number PCT/GB99/02658, filed Aug. 12, 1999, which claims priority to application serial number GB9910522.3, filed May 6, 1999, and GB9817566.4, filed Aug. 12,
Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology
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INTRODUCTION
The present invention relates to variant forms of the receptor for the obese gene product. In particular, the invention relates to methods of detecting receptor variants in the reproductive organs for the diagnosis of the cause of infertility. In addition, it relates to methods of
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
SnoRNA, compositions and uses
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CROSS-REFERENCE TO RELATED APPLICATION
This application is the U.S. national stage application of International Patent Application No. PCT/EP2014/073991, filed Nov. 7, 2014.
The Sequence Listing for this application is labeled "Seq-List-replace-2.txt" which was created on Sep. 15, 2017 and is 13 KB.
Substituted benzopyrans as selective estrogen receptor-beta agonists
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BACKGROUND OF THE INVENTION
The present invention relates to novel benzopyran ER-.beta. agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-.beta. mediated disease such as benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon
Myosin IXa and cyclic nucleotide gated channel-15 (CNGC-15) polynucleotides, polypeptides, compositions, methods, and uses thereof
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FIELD OF THE INVENTION
This invention relates to the fields of molecular biology and pharmaceutical research. More specifically, this invention relates to the identification and recombinant expression of two new genes, cyclic nucleotide gated channel-15 (CNGC-15) and Myosin IXa. Accordingly,
Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
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FIELD OF INVENTION
The present invention relates to a method of making novel dipeptidyl peptidase-IV ("DPP-IV`) inhibitor compounds and a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.
BACKGROUND OF
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
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TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Modulators of ob gene and screening methods therefor
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FIELD OF THE INVENTION
This invention relates to a method for screening for agents useful for treatment of diseases and pathological conditions affected by ob genes, and agents and compositions identified using such screening method. This invention also relates to regulatory elements and promoter
Pyridone derivatives
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This application is a U.S. national stage of International Application No. PCT/JP03/03115 filed Mar. 14, 2003.
TECHNICAL FIELD
The present invention is useful in medical fields. In more detail, novel pyridone derivatives of the present invention have an effect as neuropeptide Y receptor antagonists
Leptin agonist and methods of use
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FIELD OF THE INVENTION
The invention relates to leptin peptide fragments and their use as agonists of the leptin receptor.
BACKGROUND OF THE INVENTION
Leptin is a neurohormone that acts in the hypothalamus to regulate energy balance and food intake (M. Wauters, et al., Eur. J. Endocrinol., 2000,
Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to aminoalkyl substituted 5,6,7,8-tetrahydro-9H-pyridino[2,3-b]indole and 5,6,7,8-tetrahydro-9H-pyrimidino[4,5-b]indole derivatives, pharmaceutical compositions containing such compounds and their use in treating
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