There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 provied by the present invention can be used for treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertropy and detecting pancreatitis in various tissues including brain, prostate gland, placenta, pancreas and spleen.

FUSO Pharmaceutical Industries, Ltd.

Serine protease BSSP5

The present invention relates to a method of diagnosing an infertility condition in a human female subject, the method comprising detecting pregnancy-related serine protease (PRSP) protein in a test sample taken from said subject at between 7 and 20 weeks into pregnancy; detecting PRSP protein in a test sample from a fertile control mammal taken within the same period; and comparing the PRSP protein in the test sample with the PRSP protein detected in the control sample, wherein a change in PRSP protein in the sample compared to the control sample is indicative of an infertility condition.

Prince Henry's Institute of Medical Research

Diagnosis of fertility conditions using a serine protease

The present invention is intended to provide a specific antibody to a protein that does not have a known protein motif structure but has proteolytic activity and regulating action on the activity of other proteases, cell invasiveness and smooth muscle contraction and relaxation, and is capable of treating, preventing and diagnosing various diseases. The protein is for the treatment, prevention or diagnosis of a disease selected from the group consisting of perinatal diseases, infertility, cancer, nervous system diseases, inflammatory diseases, immune diseases, cardiovascular diseases, endocrine diseases, viral infections, bacterial infections and prion diseases, and is shown in Sequence listing 1.

Lee; Jin-Pyo

Kim; Hoon

Antibody to placental protein having a regulating action on proteolytic activity

Tapetum-specific promoters, designated A3 and A9 and capable of driving expression of 12.9 kDa and 11.6 kDa proteins in Arabidopsis thaliana and related proteins within the family Brassicaceae, have been discovered, isolated and cloned. The promoters can be used to drive male sterility DNA such as that coding for a nuclease, protease or glucanase. Alternatively or in addition, male sterility can be achieved by disrupting the proper expression of the A3 and/or A9 genes, for example by transcribing RNA which is antisense to the RNA normally transcribed from the A3 and A9 genes, or by expressing DNA coding for a ribozyme specific for at least one of the A3 and A9 genes.

infertility/protease

Serine protease BSSP5

Diagnosis of fertility conditions using a serine protease

Antibody to placental protein having a regulating action on proteolytic activity

Tapetum-specific promoters from Brassicaceae spp

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