intracranial hemorrhages/vermoeidheid

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Phase II study of sunitinib in patients with non-small cell lung cancer and irradiated brain metastases.

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BACKGROUND Brain metastases frequently cause significant morbidity in patients with non-small cell lung cancer (NSCLC). Sunitinib is a multitargeted inhibitor of tyrosine kinase receptors, including vascular endothelial growth factor receptors and platelet-derived growth factor receptors, which has

Fulminant hemophagocytic syndrome with a high interferon gamma level diagnosed as macrophage activation syndrome.

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A 26-year-old woman presented with general fatigue, persistent fever, nuchal lymphadenitis, thrombocytopenia, and liver damage. From the bone marrow finding, we diagnosed her condition as hemophagocytic syndrome. Steroid pulse therapy, cyclosporin A treatment, and combined chemotherapy generated no

[Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].

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A 30 years-old man was administrated with dizziness and fatigue for half month, and the big toe on his left foot got the prolonged bleeding of wound complicated with fever 7 days before the admission. The physical examination (PE) discovered that the case suffered from the anemic appearance, lower

Presence of Citrullinated Histone H3-Positive Neutrophils in Microscopic Polyangiitis from the Early Phase: An Autopsy Proven Case.

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A 76-year-old man was admitted with general fatigue, weight loss, fever, headache, renal failure, and a high serum level of myeloperoxidase-antineutrophil cytoplasmic antibody. Biopsy revealed citrullinated histone H3 (citH3)-positive neutrophils adherent to the temporal artery endothelium. Three

Management of sorafenib, sunitinib, and temsirolimus toxicity in metastatic renal cell carcinoma.

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OBJECTIVE To review the common and serious toxicities associated with the use of tyrosine kinase inhibitors such as sorafenib and sunitinib and mTOR inhibitor temsirolimus, and to outline the most recent toxicity management guidelines. RESULTS Common grade 3 or 4 side effects with sorafenib include

Phase II clinical study of erlotinib for treatment of myelodysplastic syndromes.

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Outcome in patients with myelodysplastic syndrome (MDS) after azanucleoside failure is poor with unmet need for active novel agents. Preclinical data have suggested that erlotinib has in vivo and in vitro off epidermal growth factor receptor (EGFR)-target activity in MDS. We conducted a phase II

Development of myelofibrosis and acute monocytic leukemia in a patient with hereditary spherocytosis: A case report.

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Common symptoms of hereditary spherocytosis (HS) include intermittent jaundice and splenomegaly. Here, we present an unusual clinical course wherein a patient with HS treated with splenectomy developed secondary myelofibrosis and acute monocytic leukemia

Paclitaxel, estramustine and carboplatin combination chemotherapy after initial docetaxel-based chemotherapy in castration-resistant prostate cancer.

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OBJECTIVE Management of castration-resistant prostate cancer after docetaxel has become an unmet need for which various agents have been investigated. We report our experience with a paclitaxel-based regimen. METHODS From February 2004 to November 2007, 15 patients (PTS) received paclitaxel 80

Neuroprotective methodologies of Co-enzyme Q10 associated mitochondrial dysfunction in post brain hemorrhagic treatment: Clinical and pre-clinical findings.

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Cerebral brain hemorrhage is associated with the highest mortality and morbidity despite only constituting approximately 10-15% of all strokes classified into intracerebral and intraventricular hemorrhage where most of the patients suffer from impairment in memory, weakness or paralysis in arms or

Neurological Complications of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-Analysis

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Background: Knowledge about neurological complications of COVID-19 in children is limited due to the paucity of data in the existing literature. Some systematic reviews are available describing overall clinical features of COVID-19 in

A Rarely Used Surgical Technique of Adult En Bloc Renal Transplant.

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OBJECTIVE We report the first en bloc adult deceased-donor renal transplant at our center. We had a an extended criteria, female, deceased donor, who was a known hypertensive, hypothyroid, with a history of Hodgkin lymphoma that had been treated successfully 30 years prior without recurrence. Her

[Chronic myeloid leukemia complicated with cerebellar hemorrhage and acute hydrocephalus successfully treated with imatinib and intensive supportive care].

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We report a case of a 46-year-old female demonstrating general fatigue and visual disturbances with retinal bleeding. She had a white blood cell count of 419,300/mm. Thereafter, she developed vomiting associated with vertigo caused by cerebellar hemorrhage, deteriorating to acute hydrocephalus

Bevacizumab in Combination with Chemotherapy for Colorectal Brain Metastasis.

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BACKGROUND Brain metastases are rare in patients with colorectal cancer, but the incidence is expected to rise due to prolonged survival resulting from more effective regimens including anti-EGF-receptor and anti-angiogenic antibodies. Because of the potential fear of intracranial hemorrhage,

Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma

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Purpose: Pediatric low-grade gliomas (pLGGs) are the most common CNS tumor of childhood and comprise a heterogenous group of tumors. Children with progressive pLGG often require numerous treatment modalities including surgery,

Phase 2 study of ABT-510 in patients with previously untreated advanced renal cell carcinoma.

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OBJECTIVE Angiogenesis is a characteristic of renal cell carcinoma. ABT-510 is an angiogenesis inhibitor that mimics the antiangiogenic properties of thrombospondin-1. This study was designed to assess the safety and efficacy of ABT-510 in patients with advanced renal cell

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