Montelukast (LTRA) administered with moderate dose of inhaled steroid

High dose of inhaled steroid administered with sugar pill

Montelukast (LTRA) administered with moderate dose of inhaled steroid
Montelukast: 10 mg Q day

Leukotriene Receptor Antagonist (LTRA) Montelukast

High dose of inhaled steroid administered with sugar pill
Sugar pill: Sugar pill that looks like Montelukast that will be given Q day

Sugar Pill

Total

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

Determine the Effect of Montelukast / Moderate Dose ICS Versus High Dose ICS on Asthma Control as Measured by the Asthma Control Questionnaire.

Serum Adiponectin, Leptin, Tumor Necrosis Alpha (TNF-α) and Interleukin 6 (IL6) Levels

Post Bronchodilator Forced Expiratory Volume in 1 Second (FEV1)

Change in Trends in Asthma Control Questionnaire (ACQ ACTQ) Scores Over Duration of the Study

Asthma exacerbation is defined as the development of an increase in asthma symptoms which results in an increase in the use of asthma medications (typically inhaled corticosteroids and/or parenteral corticosteroids) or the addition of another new asthma medication or antibiotics.

Asthma Exacerbation

Sputum Cell Counts and Differentials

Overall Study

Monica Kraft, M.D.

Asthma

Montelukast

Sugar pill that looks like Montelukast that will be given Q day

Sugar pill

Duke Asthma Allergy and Airway Center

Moderate to Persistent Asthma in the Obese Subject

A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study to Evaluate the Effect of the Leukotriene Antagonist (Singulair©) Plus Moderate Dose Beclomethasone Compared to High Dose Beclomethasone in Obese Subjects With Moderate Persistent Asthma

Duke University

juniperus communis

obesitas

obesity

juniperus communis/obesitas

Moderate to Persistent Asthma in the Obese Subject

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